Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50046401
TargetCyclin-dependent kinase 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6302(8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110179(CHEMBL190281)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50: 3.20nMAssay Description:Competitive inhibition of human CDK7 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50110180(CHEMBL3604462)
Affinity DataIC50: 4nMAssay Description:Inhibition of human CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM148264(US8962630, 74 | Ribociclib | LEE011 | Kisqali | 7-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50110187(CHEMBL3604469)
Affinity DataIC50: 32nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50110184(CHEMBL3604466)
Affinity DataIC50: 34nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM148264(US8962630, 74 | Ribociclib | LEE011 | Kisqali | 7-...)
Affinity DataIC50: 39nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110179(CHEMBL190281)
Affinity DataIC50: 43nMAssay Description:Inhibition of CDK2 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 47nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50110185(CHEMBL3604467)
Affinity DataIC50: 59nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50110186(CHEMBL3604468)
Affinity DataIC50: 122nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50113349(CHEMBL457388)
Affinity DataIC50: 140nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 200nMAssay Description:Inhibition of GSK3beta (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50113281(AT-7519 | US20240293557, Compound AMC-3-098 | US12...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK6/cyclin D3 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50110181(CHEMBL3604463)
Affinity DataIC50: 222nMAssay Description:Inhibition of human CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6302(8-cyclopentyl-6-acetyl-5-methyl-2-{[4-(piperazin-1...)
Affinity DataIC50: 230nMAssay Description:Inhibition of CDK2 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110185(CHEMBL3604467)
Affinity DataIC50: 403nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6301(6-bromo-8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-...)
Affinity DataIC50: 439nMAssay Description:Inhibition of CDK2 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110184(CHEMBL3604466)
Affinity DataIC50: 514nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6221(8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 620nMAssay Description:Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50113282(CHEMBL456163)
Affinity DataIC50: 850nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50113349(CHEMBL457388)
Affinity DataIC50: 980nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50110182(CHEMBL3604464)
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of human CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of human CDK1/cyclin B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM24634(N-phenyl-1H-indazole-3-carboxamide | indazole amid...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin) expressed in baculovirus infected insect cells using GST-fused pRb (792 to 928) as substrate preincubated for 2 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110187(CHEMBL3604469)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of carbonic anhydrase-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50088360(Purpurogallin | purpurogalline | 2,3,4,6-tetrahydr...)
Affinity DataIC50: 1.70E+4nMAssay Description:Competitive inhibition of human CDK2/cyclinA using PKTPKKAKKL as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50110177(CHEMBL3604461)
Affinity DataIC50: 2.70E+4nMAssay Description:Non-competitive inhibition of human CDK2/cyclinA using PKTPKKAKKL as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50110175(CHEMBL3604459)
Affinity DataIC50: 4.50E+4nMAssay Description:Competitive inhibition of human CDK2/cyclinA using PKTPKKAKKL as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50110176(CHEMBL3604460)
Affinity DataIC50: 7.10E+4nMAssay Description:Non-competitive inhibition of human CDK2/cyclinA using PKTPKKAKKL as substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM24627(Indazole, 5 | 1H-indazole | Indazole, 6)
Affinity DataIC50: 1.85E+5nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataKi:  8.20nMAssay Description:Competitive inhibition of CDK6/cyclin D3 (unknown origin) assessed as phosphorylation of CTRF after 50 mins by Michaelis-Menten plot analysis in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed