Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50046381
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM50110590(5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid...)
Affinity DataKd:  100nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKd:  70nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM7458(Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataKd:  250nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  580nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataKd:  150nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM22971(Meclofenamate | CHEMBL509 | 2-[(2,6-dichloro-3-met...)
Affinity DataKd:  480nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM85507(NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...)
Affinity DataKd:  260nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM13066({2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM50109016(CHEBI:31159 | Aceclofenac)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: 7.00E+3nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM7458(Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...)
Affinity DataIC50: 1.80E+4nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataIC50: 2.50E+4nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM35905(cid_610479 | flufenamic acid analogue, 32 | Tolfen...)
Affinity DataIC50: 4.00E+4nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM22971(Meclofenamate | CHEMBL509 | 2-[(2,6-dichloro-3-met...)
Affinity DataIC50: 5.00E+4nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM85507(NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...)
Affinity DataIC50: 1.30E+5nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM13066({2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |...)
Affinity DataIC50: 1.40E+5nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM50109016(CHEBI:31159 | Aceclofenac)
Affinity DataIC50: 1.70E+5nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetTransthyretin(Human)
Ume£

Curated by ChEMBL
LigandPNGBDBM50110590(5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid...)
Affinity DataIC50: 1.80E+5nMAssay Description:Binding affinity to TTR in human plasma assessed as protein stabilization preincubated for 1 hr followed by urea-mediated denaturation by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)