Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50046632
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataKd:  360nMAssay Description:Binding affinity to JAK3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataKd:  0.480nMAssay Description:Binding affinity to JAK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataKd:  110nMAssay Description:Binding affinity to JAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataEC50: >5.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122323(CHEMBL3622146)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122326(CHEMBL3622143)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122319(CHEMBL3622150)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122327(CHEMBL3622142)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122324(CHEMBL3622145)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122321(CHEMBL3622148)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122319(CHEMBL3622150)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122325(CHEMBL3622144)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122319(CHEMBL3622150)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122326(CHEMBL3622143)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122326(CHEMBL3622143)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122325(CHEMBL3622144)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122323(CHEMBL3622146)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122322(CHEMBL3622147)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122324(CHEMBL3622145)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122323(CHEMBL3622146)
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122325(CHEMBL3622144)
Affinity DataIC50: 49nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122324(CHEMBL3622145)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Mouse)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataIC50: 65nMAssay Description:Inhibition of JAK2 in mouse BAF3 cells assessed as reduction in STAT5 phosphorylation incubated for 2 hrs by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataIC50: 66nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataIC50: 80nMAssay Description:Inhibition of JAK2 in human SET2 cells assessed as reduction in STAT5 phosphorylation incubated for 2 hrs by Western blot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122319(CHEMBL3622150)
Affinity DataIC50: 87nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122321(CHEMBL3622148)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122321(CHEMBL3622148)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122320(CHEMBL3622149)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122327(CHEMBL3622142)
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122321(CHEMBL3622148)
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122327(CHEMBL3622142)
Affinity DataIC50: 460nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122320(CHEMBL3622149)
Affinity DataIC50: 540nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122320(CHEMBL3622149)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122322(CHEMBL3622147)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122320(CHEMBL3622149)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122318(BMS-911543)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM50122322(CHEMBL3622147)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2016
Entry Details Article
PubMed