Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50046771
TargetTranslocator protein(Rat)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM22032(PK 11195 | PK11195 | RP 52028 | N-(butan-2-yl)-1-(...)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in Sprague-Dawley rat cerebral cortex membrane by radiometric competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP2D6 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2C19(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM30130(Prozac | cid_62857 | Fluoxetin | CHEMBL41 | CHEMBL...)
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2C19 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM31768(Nizoral | CHEMBL295698 | Panfungol | Ketoconazole)
Affinity DataIC50: 60nMAssay Description:Inhibition of CYP3A4 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50090677(CHEMBL1109 | 4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-...)
Affinity DataIC50: 80nMAssay Description:Inhibition of CYP2C9 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataIC50: 194nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in Sprague-Dawley rat cerebral cortex membrane by radiometric competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50236897(furafylline | 3-(furan-2-ylmethyl)-1,8-dimethyl-1H...)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP1A2 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130509(CHEMBL3634097)
Affinity DataIC50: 447nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in Sprague-Dawley rat cerebral cortex membrane by radiometric competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130506(CHEMBL3634110)
Affinity DataIC50: 703nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in Sprague-Dawley rat cerebral cortex membrane by radiometric competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130505(CHEMBL3634101)
Affinity DataIC50: 722nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in Sprague-Dawley rat cerebral cortex membrane by radiometric competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130507(CHEMBL3634109)
Affinity DataIC50: 1.32E+3nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in Sprague-Dawley rat cerebral cortex membrane by radiometric competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetTranslocator protein(Rat)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130508(CHEMBL3634099)
Affinity DataIC50: 2.79E+3nMAssay Description:Displacement of [3H]PK11195 from TSPO receptor in Sprague-Dawley rat cerebral cortex membrane by radiometric competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130505(CHEMBL3634101)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130505(CHEMBL3634101)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130505(CHEMBL3634101)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130505(CHEMBL3634101)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]astemizole from human ERG potassium channel expressed in HEK293 cell membrane after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130505(CHEMBL3634101)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Korea University of Science and Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50130505(CHEMBL3634101)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed