Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50006336
TargetG-protein coupled bile acid receptor 1(Human)
Heinrich Heine University

Curated by ChEMBL
LigandPNGBDBM50375595(CHEMBL185878 | Taurochenodeoxycholate)
Affinity DataEC50:  2.96E+4nMAssay Description:Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Heinrich Heine University

Curated by ChEMBL
LigandPNGBDBM50375592(CHEMBL412272)
Affinity DataEC50:  8.90E+3nMAssay Description:Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Heinrich Heine University

Curated by ChEMBL
LigandPNGBDBM50236230(ursodeoxy cholic acid | 2-((R)-4-((3R,5S,7S,8R,9S,...)
Affinity DataEC50:  5.05E+4nMAssay Description:Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Heinrich Heine University

Curated by ChEMBL
LigandPNGBDBM50375595(CHEMBL185878 | Taurochenodeoxycholate)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Heinrich Heine University

Curated by ChEMBL
LigandPNGBDBM50375592(CHEMBL412272)
Affinity DataEC50:  680nMAssay Description:Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Heinrich Heine University

Curated by ChEMBL
LigandPNGBDBM50236230(ursodeoxy cholic acid | 2-((R)-4-((3R,5S,7S,8R,9S,...)
Affinity DataEC50:  1.05E+5nMAssay Description:Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed