Compile Data Set for Download or QSAR
Report error Found 115 Enz. Inhib. hit(s) with all data for entry = 50006480
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0260nMAssay Description:Binding affinity to NPY1R in human SK-N-MC cells assessed as kinetically derived dissociation rate constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.0370nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0400nMAssay Description:Binding affinity to NPY1R in human SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0440nMAssay Description:Binding affinity to NPY1R in human SK-N-MC cells after 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0480nMAssay Description:Binding affinity to NPY1R in human SK-N-MC cells by Scatchard plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50: 0.0501nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50: 0.0501nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50: 0.0631nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0740nMAssay Description:Binding affinity to NPY1R in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataKi:  0.0770nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.0830nMAssay Description:Binding affinity to NPY1R in human MCF7-Y1 cells by Scatchard plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500154(CHEMBL3746870)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500154(CHEMBL3746870)
Affinity DataIC50: 0.105nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataIC50: 0.120nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50: 0.126nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataIC50: 0.129nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500155(CHEMBL3747715)
Affinity DataKd:  0.140nMAssay Description:Binding affinity to NPY1R in human MCF7 cells after 90 mins by microbeta2 plate counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500154(CHEMBL3746870)
Affinity DataIC50: 0.151nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50: 0.151nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500154(CHEMBL3746870)
Affinity DataIC50: 0.162nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataIC50: 0.170nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataIC50: 0.170nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataIC50: 0.170nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500153(CHEMBL3746851)
Affinity DataIC50: 0.195nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500153(CHEMBL3746851)
Affinity DataIC50: 0.219nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataIC50: 0.240nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500154(CHEMBL3746870)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataIC50: 0.324nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500154(CHEMBL3746870)
Affinity DataIC50: 0.331nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500153(CHEMBL3746851)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500153(CHEMBL3746851)
Affinity DataIC50: 0.347nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246648((R)-1-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylac...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500157(CHEMBL4299523)
Affinity DataKi:  0.410nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500151(CHEMBL3746386)
Affinity DataIC50: 0.417nMAssay Description:Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50500157(CHEMBL4299523)
Affinity DataKi:  0.420nMAssay Description:Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Cnrs/Ipbs (Institut De Pharmacologie Et Biologie Structurale)

Curated by ChEMBL
LigandPNGBDBM50246649((R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-d...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
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