Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50047507
TargetVascular endothelial growth factor receptor 2(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoropheny...)
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of human recombinant full length VEGFR2 using poly (Glu,Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human full length MET by scintillation counting method in presence of 33P-gammaATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 2(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM144315(US8969336, 577 | US8969336, 547 | Gilteritinib | U...)
Affinity DataIC50: 1nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM24498(CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SRC (1 to 530 residues) using GGEEEEYFELVKKKK as substrate after 40 mins by scintillation counting analysis in presence of [gamma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human ABL using EAIYAAPFAKKK as substrate after 40 mins by scintillation counting analysis in presence of [gamma-33P-ATP]More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MEK1 after 40 mins in presence of MgATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human BMX using poly(Glu,Tyr) 4:1 as substrate after 40 mins by scintillation counting analysis in presence of [gamma-33P-ATP]More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM24498(CHEMBL254760 | 3-(3-fluoro-4-{[2-(1-methyl-1H-imid...)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoropheny...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant full length MET using poly (Glu,Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoropheny...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of VEGFR2 in human MDA-MB-231 cells assessed as receptor phosphorylation after 1 to 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length AXL after 4 hrs followed by stimulation with human recombinant Gas6 for 15 minutes by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoropheny...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant full length AXL using poly (Glu,Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172080(CHEMBL3808948)
Affinity DataIC50: 7nMAssay Description:Inhibition of human AXL by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoropheny...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of MET in human MDA-MB-231 cells assessed as receptor phosphorylation after 1 to 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant AXL expressed in Escherichia coli BL21 infected with T7 phage by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant AXL expressed in Escherichia coli BL21 infected with T7 phage by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: 11nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172078(LY-2801653 | Merestinib | US11952364, Example Mere...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human full length AXL by scintillation counting method in presence of 33P-gammaATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant AXL by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172075(CHEMBL3808844 | US11053225, Positive control (LDC1...)
Affinity DataIC50: 19nMAssay Description:Inhibition of AXL in human Hs578t cells by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant AXL in human HeLa cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50248510(N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluoropheny...)
Affinity DataIC50: 42nMAssay Description:Inhibition of AXL in human MDA-MB-231 cells assessed as receptor phosphorylation after 1 to 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 48nMAssay Description:Inhibition of human recombinant MET expressed in Escherichia coli BL21 infected with T7 phage by qPCR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172080(CHEMBL3808948)
Affinity DataIC50: 56nMAssay Description:Inhibition of human AXL expressed in MEF cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172076(CHEMBL3809908)
Affinity DataIC50: 58nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: 100nMAssay Description:Inhibition of AXL in lapatinib-sensitive human BT474 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 340nMAssay Description:Inhibition of AXL (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172077(CHEMBL3810063)
Affinity DataIC50: 500nMAssay Description:Inhibition of AXL (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 560nMAssay Description:Inhibition of human AXL by scintillation counting method in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant TYRO3 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Mer(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant MER by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172079(CHEMBL3809489 | US20250026773, Positive Drug 1 BGB...)
Affinity DataIC50: 700nMAssay Description:Inhibition of human recombinant ABL by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172081(Amuvatinib | HPK-56 | HPK56 | MP-470)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of AXL in human GIST cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50172076(CHEMBL3809908)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of AXL (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed