Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50006520
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM50500540(CHEMBL3747767)
Affinity DataIC50: 230nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106221(US9695174, Ko134)
Affinity DataIC50: 230nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM50500541(CHEMBL3747380)
Affinity DataIC50: 230nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106203(US9695174, I-1)
Affinity DataIC50: 600nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106209(US9695174, 4)
Affinity DataIC50: 610nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106203(US9695174, I-1)
Affinity DataIC50: 610nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106157(US9695174, 8)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM50500539(CHEMBL3746825)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106207(US9695174, 12)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106216(US9695174, 12A)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate assessed as Ko143 IC50 measured at 30 to 120 mins by microplate scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106207(US9695174, 12)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106221(US9695174, Ko134)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM50500541(CHEMBL3747380)
Affinity DataIC50: 3.87E+3nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM50500539(CHEMBL3746825)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106209(US9695174, 4)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106216(US9695174, 12A)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM106157(US9695174, 8)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Takeda Pharmaceuticals International

Curated by ChEMBL
LigandPNGBDBM50500540(CHEMBL3747767)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BCRP in human Caco2 cells using 3H-Estron-3-sulfate as substrate measured at 30 to 120 mins by microplate scintillation and luminescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed