Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 50047112
TargetEgl nine homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50: 280nMAssay Description:Inhibition of PHD2 (unknown origin) using biotinylated HIF-1alpha (558 to 574 residues) as substrate after 1 hr by homogeneous time-resolved fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193145(Isoquinoline 3 | CHEMBL426560 | N-[(1-CHLORO-4-HYD...)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant PHD2 (unknown origin) catalytic domain (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) cells using boitinyla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193145(Isoquinoline 3 | CHEMBL426560 | N-[(1-CHLORO-4-HYD...)
Affinity DataIC50: 424nMAssay Description:Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEgl nine homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US9115085, Compound A Form A | US9...)
Affinity DataIC50: 591nMAssay Description:Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM107698(US8722895, 4: [(3-Hydroxy-5-(4-methylphenyl)pyridi...)
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant human PHD2 (179 to 426 residues) using HIF-1alpha (556 to 574 residues) as substrate after 20 mins by MALDI-TOF MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50: 876nMAssay Description:Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM107698(US8722895, 4: [(3-Hydroxy-5-(4-methylphenyl)pyridi...)
Affinity DataIC50: 890nMAssay Description:Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2017
Entry Details Article
PubMed