Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50046953
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50: 3nMAssay Description:Inhibition of SK1 (unknown origin) using 3 uM of sphingosine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50139648(CHEMBL3763321)
Affinity DataIC50: 20nMAssay Description:Inhibition of SK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50: 28nMAssay Description:Inhibition of SK1 (unknown origin) using 5 uM of sphingosine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50139648(CHEMBL3763321)
Affinity DataIC50: 148nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50: 387nMAssay Description:Inhibition of recombinant His-tagged human SK1 assessed as production of [32P]-S1P using 10 uM sphingosine as substrate by TLC method in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50139652(CHEMBL3764032)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human SK2 using D-erythro sphingosine as substrate and gamma[33P]ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50139651(CHEMBL3763496)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of SK1 (unknown origin) using 5 uM of sphingosine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50139651(CHEMBL3763496)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of human SK2 using D-erythro sphingosine as substrate and gamma[33P]ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of recombinant human SK2 assessed as production of [32P] S1P using 10 uM sphingosine as substrate by TLC method in presence of 100 uM [gam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50139652(CHEMBL3764032)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SK1 (unknown origin) using 5 uM of sphingosine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataKi:  4nMAssay Description:Inhibition of SK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50343835((S)-1-(4-(4-(3-(2-Cyclohexylethyl)phenyl)oxazol-2-...)
Affinity DataKi:  47nMAssay Description:Inhibition of SK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50139650(US9688668, 50 | CHEMBL3546834)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of recombinant SK2 (unknown origin) expressed in Sf9 cells assessed as [33P]S1P formation using D-erythro sphingosine as substrate and gam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50343835((S)-1-(4-(4-(3-(2-Cyclohexylethyl)phenyl)oxazol-2-...)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of recombinant SK2 (unknown origin) using sphingosine as substrate and gamma[32P]ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50139649(CHEMBL3764617)
Affinity DataKi:  6.90E+3nMAssay Description:Inhibition of human SK2 using D-erythro sphingosine as substrate and gamma[33P]ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50312869(N-aryl-4-aryl-1,3-thiazole-2-amine, 5 | CHEMBL1076...)
Affinity DataKi:  7.90E+3nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50393642(CHEMBL2158685)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50139650(US9688668, 50 | CHEMBL3546834)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of recombinant SK1 (unknown origin) expressed in Sf9 cells assessed as [33P]S1P formation using D-erythro sphingosine as substrate and gam...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50312869(N-aryl-4-aryl-1,3-thiazole-2-amine, 5 | CHEMBL1076...)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of SK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50139649(CHEMBL3764617)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of human SK1 using D-erythro sphingosine as substrate and gamma[33P]ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed