Compile Data Set for Download or QSAR
Report error Found 69 Enz. Inhib. hit(s) with all data for entry = 50018775
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612431(CHEMBL5270123)
Affinity DataIC50: 0.400nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612411(CHEMBL5270816)
Affinity DataEC50:  0.430nMAssay Description:Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612414(CHEMBL5285528)
Affinity DataEC50: <0.5nMAssay Description:Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612402(CHEMBL5290871)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612437(CHEMBL5282114)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human GST-tagged FXR LBD (193 to 472 residues) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612418(CHEMBL5284434)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50301754(isopropyl 2-cyano-6-(3-fluorobenzoyl)-4,4-dimethyl...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human Gal4-fused FXR expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50250863(CHEMBL4062760)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human GST-tagged FXR LBD (193 to 472 residues) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612419(CHEMBL5268028)
Affinity DataEC50:  5.60nMAssay Description:Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612404(CHEMBL5272181)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612401(CHEMBL5280567)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612395(CHEMBL5283173)
Affinity DataEC50:  7nMAssay Description:Agonist activity at TGR5 in human T-lymphocyte cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612434(CHEMBL5272711)
Affinity DataEC50:  7.70nMAssay Description:Agonist activity at FXR (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM411309(N-[4-(4-Fluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-m...)
Affinity DataEC50:  9nMAssay Description:Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50399965(CHEMBL2181246)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human TGR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50185706(CHEMBL3822803)
Affinity DataEC50:  10nMAssay Description:Agonist activity at GAL4-fused N-terminal GST tagged human FXR LBD expressed in human HEK293 cells by one hybrid reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50185722(CHEMBL3824207)
Affinity DataEC50:  10nMAssay Description:Agonist activity at GAL4-fused N-terminal GST tagged human FXR LBD expressed in human HEK293 cells by one hybrid reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612424(CHEMBL5286949)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human TGR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612420(CHEMBL5276894)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161834(CHEMBL3794175)
Affinity DataEC50:  17nMAssay Description:Agonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612432(CHEMBL5285068)
Affinity DataIC50: 17nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612430(CHEMBL5270197)
Affinity DataIC50: 20nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612396(CHEMBL5270683)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612397(CHEMBL5284578)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50185722(CHEMBL3824207)
Affinity DataEC50: <25nMAssay Description:Agonist activity at FXR (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612403(CHEMBL5281639)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612435(CHEMBL5267828)
Affinity DataEC50:  64nMAssay Description:Agonist activity at human GST-tagged FXR LBD (193 to 472 residues) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612399(CHEMBL5267358)
Affinity DataEC50:  75nMAssay Description:Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612422(CHEMBL5281159)
Affinity DataEC50:  76nMAssay Description:Agonist activity at human TGR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612421(CHEMBL5274626)
Affinity DataEC50:  79nMAssay Description:Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612400(CHEMBL5272787)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612436(CHEMBL5285178)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human GST-tagged FXR LBD (193 to 472 residues) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612429(CHEMBL5278582)
Affinity DataEC50: <100nMAssay Description:Agonist activity at human FXR expressed in Escherichia coli BL21 (DE3) assessed as effect on europium labeled SRC-1 peptide recruitment by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612409(CHEMBL5291142)
Affinity DataEC50: <100nMAssay Description:Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50161834(CHEMBL3794175)
Affinity DataEC50: <100nMAssay Description:Agonist activity at TGR5 in human HEK293 cells incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612398(CHEMBL5278768)
Affinity DataEC50: <100nMAssay Description:Agonist activity at TGR5 in human HEK293 cells incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612433(CHEMBL5276371)
Affinity DataIC50: 155nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612410(CHEMBL5268940)
Affinity DataEC50:  220nMAssay Description:Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612413(CHEMBL5286375)
Affinity DataEC50:  229nMAssay Description:Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612435(CHEMBL5267828)
Affinity DataEC50:  245nMAssay Description:Agonist activity at human GST-tagged FXR LBD (193 to 472 residues) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50301761(isopropyl 2-cyano-6-(3,4-difluorobenzoyl)-4,4-dime...)
Affinity DataEC50:  280nMAssay Description:Agonist activity at human Gal4-fused FXR expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Mouse)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612422(CHEMBL5281159)
Affinity DataEC50:  350nMAssay Description:Agonist activity at mouse TGR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612423(CHEMBL5279619)
Affinity DataEC50:  396nMAssay Description:Agonist activity at human TGR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612427(CHEMBL5279162)
Affinity DataEC50:  800nMAssay Description:Agonist activity at FXR transfected in human NCI-H716 cells assessed as increase in cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612428(CHEMBL5268840)
Affinity DataEC50:  1.95E+3nMAssay Description:Agonist activity at human FXR transfected in African green monkey CV-1 cells assessed as receptor transactivationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Mouse)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50612423(CHEMBL5279619)
Affinity DataEC50:  2.02E+3nMAssay Description:Agonist activity at mouse TGR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Mouse)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50399965(CHEMBL2181246)
Affinity DataEC50:  2.56E+3nMAssay Description:Agonist activity at mouse TGR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataIC50: 2.60E+3nMAssay Description:Antagonist activity at FXR in human HepG2 cells incubated for 24 hrs by dual luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM21676((2S,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50:  3.58E+3nMAssay Description:Agonist activity at TGR5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM21723(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(4-pheny...)
Affinity DataIC50: 3.70E+3nMAssay Description:Antagonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
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