Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50011699
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataIC50: 3nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM178085(US9675614, 188 | US10307413, Compound 188 | US1039...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM177922(US9675614, 166 | US10307413, Compound 337 | US1039...)
Affinity DataIC50: 9nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM336999(US9765068, Compound 45 | US9745291, Compound 269 |...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM176872(US9675614, 44 | US10307413, Compound 44 | US103910...)
Affinity DataIC50: 13nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM176815(US9675614, 1 | US10307413, Compound 1 | US10391089...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM176841(US9675614, 20 | US10307413, Compound 20 | US103910...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM336999(US9765068, Compound 45 | US9745291, Compound 269 |...)
Affinity DataIC50: 16nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM176872(US9675614, 44 | US10307413, Compound 44 | US103910...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM177922(US9675614, 166 | US10307413, Compound 337 | US1039...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM336960(US9765068, Compound 6 | US9745291, Compound 6)
Affinity DataIC50: 23nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM176841(US9675614, 20 | US10307413, Compound 20 | US103910...)
Affinity DataIC50: 32nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM343824(1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-((4-(1-methy...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM336960(US9765068, Compound 6 | US9745291, Compound 6)
Affinity DataIC50: 36nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM176815(US9675614, 1 | US10307413, Compound 1 | US10391089...)
Affinity DataIC50: 37nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM343751(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-methyl...)
Affinity DataIC50: 73nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM176840(US9675614, 19 | US10307413, Compound 19 | US103910...)
Affinity DataIC50: 95nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM336998(US9765068, Compound 44 | US9745291, Compound 44)
Affinity DataIC50: 144nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM343824(1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-((4-(1-methy...)
Affinity DataIC50: 180nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM343707(US9777008, Compound 1)
Affinity DataIC50: 326nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM336998(US9765068, Compound 44 | US9745291, Compound 44)
Affinity DataIC50: 327nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM176840(US9675614, 19 | US10307413, Compound 19 | US103910...)
Affinity DataIC50: 406nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Epizyme

Curated by ChEMBL
LigandPNGBDBM343751(1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(1-methyl...)
Affinity DataIC50: 435nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM297741(US10118918, Compound 20 | 1-(3-((cyclopentylamino)...)
Affinity DataIC50: 7.45E+3nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50550144(CHEMBL4754920)
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50550145(CHEMBL4764863)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM343736(US9777008, Compound 30)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed