Compile Data Set for Download or QSAR
Report error Found 78 Enz. Inhib. hit(s) with all data for entry = 50006580
LigandPNGBDBM50017659(Diaethylaminoaethanol ester der p-butylaminobenzoe...)
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500962(CHEMBL3798242)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500957(CHEMBL3798039)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344740(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-[(6-methy...)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500965(CHEMBL3799372)
Affinity DataIC50: 320nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50017659(Diaethylaminoaethanol ester der p-butylaminobenzoe...)
Affinity DataIC50: 320nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by voltage-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344718(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500958(CHEMBL3798320)
Affinity DataIC50: 340nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by voltage-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344708(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)
Affinity DataIC50: 370nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344708(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)
Affinity DataIC50: 480nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50017659(Diaethylaminoaethanol ester der p-butylaminobenzoe...)
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant human Nav1.2 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50017659(Diaethylaminoaethanol ester der p-butylaminobenzoe...)
Affinity DataIC50: 520nMAssay Description:Inhibition of recombinant human Nav1.6 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500957(CHEMBL3798039)
Affinity DataIC50: 540nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344706(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(4-methyl...)
Affinity DataIC50: 570nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344708(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)
Affinity DataIC50: 570nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by voltage-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500956(CHEMBL3800069)
Affinity DataIC50: 580nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500966(CHEMBL3797487)
Affinity DataIC50: 580nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500962(CHEMBL3798242)
Affinity DataIC50: 620nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50017659(Diaethylaminoaethanol ester der p-butylaminobenzoe...)
Affinity DataIC50: 650nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344699(tert-butyl 3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-...)
Affinity DataIC50: 730nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50017659(Diaethylaminoaethanol ester der p-butylaminobenzoe...)
Affinity DataIC50: 740nMAssay Description:Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500963(CHEMBL3798493)
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344698(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-[2-oxo-2-...)
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344700(2-{3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-2-oxoimi...)
Affinity DataIC50: 840nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344771(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3R)-...)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344711(N-cyclopropyl-2-{3-[1-(2-fluorophenyl)-1H-indazol-...)
Affinity DataIC50: 920nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500964(CHEMBL3799617)
Affinity DataIC50: 960nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344698(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-[2-oxo-2-...)
Affinity DataIC50: 990nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500963(CHEMBL3798493)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344752(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344711(N-cyclopropyl-2-{3-[1-(2-fluorophenyl)-1H-indazol-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500955(CHEMBL3797315)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500965(CHEMBL3799372)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500959(CHEMBL3799939)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500963(CHEMBL3798493)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344729(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(1,3-oxaz...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344718(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500961(CHEMBL3798363)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500955(CHEMBL3797315)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500960(CHEMBL3800304)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344699(tert-butyl 3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500956(CHEMBL3800069)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344700(2-{3-[1-(2-fluorophenyl)-1H-indazol-4-yl]-2-oxoimi...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500961(CHEMBL3798363)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of recombinant human Nav1.2 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500954(CHEMBL3799951)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500961(CHEMBL3798363)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293F cells measured at -65 mV holding potential by Qpatch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344705(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500961(CHEMBL3798363)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM344718(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-(pyridin-...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
LigandPNGBDBM50500961(CHEMBL3798363)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
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