Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50006583
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM24226(cid_2247 | [3H]-ASTEMIZOLE | Hismanal | ASTEMIZOLE...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human ERG assessed as reduction in channel current by automated patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human C-RAF measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500971(CHEMBL3798983)
Affinity DataIC50: 15nMAssay Description:Inhibition of human C-RAF measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 38nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500971(CHEMBL3798983)
Affinity DataIC50: 95nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500969(CHEMBL3799746)
Affinity DataIC50: 111nMAssay Description:Inhibition of human C-RAF measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500969(CHEMBL3799746)
Affinity DataIC50: 131nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500970(CHEMBL3797601)
Affinity DataIC50: 566nMAssay Description:Inhibition of human C-RAF measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500968(CHEMBL3799621)
Affinity DataIC50: 695nMAssay Description:Inhibition of human C-RAF measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500970(CHEMBL3797601)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500968(CHEMBL3799621)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) measured after 40 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500968(CHEMBL3799621)
Affinity DataIC50: 4.84E+4nMAssay Description:Inhibition of human ERG assessed as reduction in channel current by automated patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500971(CHEMBL3798983)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG assessed as reduction in channel current by automated patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500969(CHEMBL3799746)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG assessed as reduction in channel current by automated patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Korea Institute of Science & Technology (Kist)

Curated by ChEMBL
LigandPNGBDBM50500970(CHEMBL3797601)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG assessed as reduction in channel current by automated patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed