Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 7309
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 25nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 29nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 33nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 40nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 62nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 140nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 170nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM50438865(CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...)
Affinity DataIC50: 180nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438865(CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...)
Affinity DataIC50: 260nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM50438865(CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...)
Affinity DataIC50: 300nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 580nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 710nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 1.10E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2 [Q278R,I281T,K282R,P318T,Y321C](Mouse)
National Institutes of Health

LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 1.20E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM50438870(CHEMBL2420501 | 8-Chloro-10-(4-hydroxyphenyl)pyrim...)
Affinity DataIC50: 2.30E+3nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438865(CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...)
Affinity DataIC50: 3.70E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM50438870(CHEMBL2420501 | 8-Chloro-10-(4-hydroxyphenyl)pyrim...)
Affinity DataIC50: 3.90E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438870(CHEMBL2420501 | 8-Chloro-10-(4-hydroxyphenyl)pyrim...)
Affinity DataIC50: 4.00E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM50438882(CHEMBL471342 | 10-Phenylpyrimido[4,5-b]quinoline-2...)
Affinity DataIC50: 2.00E+4nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438870(CHEMBL2420501 | 8-Chloro-10-(4-hydroxyphenyl)pyrim...)
Affinity DataIC50: 3.50E+4nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438882(CHEMBL471342 | 10-Phenylpyrimido[4,5-b]quinoline-2...)
Affinity DataIC50: 7.10E+4nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Human)
National Institutes of Health

LigandPNGBDBM50438882(CHEMBL471342 | 10-Phenylpyrimido[4,5-b]quinoline-2...)
Affinity DataIC50: 7.10E+4nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
National Institutes of Health

LigandPNGBDBM50438882(CHEMBL471342 | 10-Phenylpyrimido[4,5-b]quinoline-2...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438882(CHEMBL471342 | 10-Phenylpyrimido[4,5-b]quinoline-2...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
National Institutes of Health

LigandPNGBDBM50438870(CHEMBL2420501 | 8-Chloro-10-(4-hydroxyphenyl)pyrim...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
National Institutes of Health

LigandPNGBDBM50438865(CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
National Institutes of Health

LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
National Institutes of Health

LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed