Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50047714
TargetVitamin D3 receptor(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at VDR expressed in human HuH7 cells after 24 hrs by pDR3-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  20nMAssay Description:Agonist activity at CAR LBD (108 to 348 residues) expressed in human HepG2 cells assessed as receptor binding to PGC1alpha by lanthascreenTR-FRET coa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50014323(CHEMBL283196 | alpha-naphthoflavone | 2-PHENYL-4H-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human CYP1A2 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human CYP2D6 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 1A2(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185307(CHEMBL3822473)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human CYP1A2 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50370232(BA-41166E | L-5103 | Rifadin | Rifampicin | RIFAMP...)
Affinity DataEC50:  190nMAssay Description:Agonist activity at PXR expressed in human HepG2 cells after 24 hrs by p3A4-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human CYP3A4 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185305(CHEMBL3822867)
Affinity DataIC50: 420nMAssay Description:Inhibition of recombinant human CYP1A2 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetAryl hydrocarbon receptor(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM181120(US9138393, Methyl- cholanthrene | US9144538, Methy...)
Affinity DataEC50:  490nMAssay Description:Agonist activity at AHR expressed in human HepG2 cells after 24 hrs by pXRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185306(CHEMBL3823873)
Affinity DataEC50:  510nMAssay Description:Agonist activity at VDR expressed in human HuH7 cells after 24 hrs by pDR3-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  510nMAssay Description:Agonist activity at human CAR3 expressed in African green monkey COS-1 cells cotransfected with RXRalpha after 24 hrs by CYP2B6-luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM85509(NSC_5472 | CAS_55142-85-3 | Ticlopidine)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human CYP2B6 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetAryl hydrocarbon receptor(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185306(CHEMBL3823873)
Affinity DataEC50:  630nMAssay Description:Agonist activity at AHR expressed in human HepG2 cells after 24 hrs by pXRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185306(CHEMBL3823873)
Affinity DataEC50:  690nMAssay Description:Agonist activity at CAR LBD (108 to 348 residues) expressed in human HepG2 cells assessed as receptor binding to PGC1alpha by lanthascreenTR-FRET coa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185306(CHEMBL3823873)
Affinity DataIC50: 750nMAssay Description:Inhibition of recombinant human CYP1A2 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185306(CHEMBL3823873)
Affinity DataEC50:  860nMAssay Description:Agonist activity at PXR expressed in human HepG2 cells after 24 hrs by p3A4-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185307(CHEMBL3822473)
Affinity DataEC50:  1.95E+3nMAssay Description:Agonist activity at VDR expressed in human HuH7 cells after 24 hrs by pDR3-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185307(CHEMBL3822473)
Affinity DataEC50:  2.07E+3nMAssay Description:Agonist activity at CAR LBD (108 to 348 residues) expressed in human HepG2 cells assessed as receptor binding to PGC1alpha by lanthascreenTR-FRET coa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetAryl hydrocarbon receptor(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185305(CHEMBL3822867)
Affinity DataEC50:  2.30E+3nMAssay Description:Agonist activity at AHR expressed in human HepG2 cells after 24 hrs by pXRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185307(CHEMBL3822473)
Affinity DataEC50: >3.00E+3nMAssay Description:Agonist activity at PXR expressed in human HepG2 cells after 24 hrs by p3A4-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185305(CHEMBL3822867)
Affinity DataEC50: >3.00E+3nMAssay Description:Agonist activity at VDR expressed in human HuH7 cells after 24 hrs by pDR3-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185305(CHEMBL3822867)
Affinity DataEC50: >3.50E+3nMAssay Description:Agonist activity at PXR expressed in human HepG2 cells after 24 hrs by p3A4-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185305(CHEMBL3822867)
Affinity DataEC50:  4.04E+3nMAssay Description:Agonist activity at human CAR3 expressed in African green monkey COS-1 cells cotransfected with RXRalpha after 24 hrs by CYP2B6-luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185305(CHEMBL3822867)
Affinity DataIC50: 4.19E+3nMAssay Description:Inhibition of recombinant human CYP2C9 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185307(CHEMBL3822473)
Affinity DataEC50:  4.91E+3nMAssay Description:Agonist activity at human CAR3 expressed in African green monkey COS-1 cells cotransfected with RXRalpha after 24 hrs by CYP2B6-luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185307(CHEMBL3822473)
Affinity DataIC50: 5.03E+3nMAssay Description:Inhibition of recombinant human CYP2C9 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185305(CHEMBL3822867)
Affinity DataEC50:  5.12E+3nMAssay Description:Agonist activity at CAR LBD (108 to 348 residues) expressed in human HepG2 cells assessed as receptor binding to PGC1alpha by lanthascreenTR-FRET coa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185306(CHEMBL3823873)
Affinity DataEC50:  6.12E+3nMAssay Description:Agonist activity at human CAR3 expressed in African green monkey COS-1 cells cotransfected with RXRalpha after 24 hrs by CYP2B6-luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetAryl hydrocarbon receptor(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185307(CHEMBL3822473)
Affinity DataEC50:  7.30E+3nMAssay Description:Agonist activity at AHR expressed in human HepG2 cells after 24 hrs by pXRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM25817(Fungata | Diflucan | Fluconazole (f) | cid_3365 | ...)
Affinity DataIC50: 9.21E+3nMAssay Description:Inhibition of recombinant human CYP2C9 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185306(CHEMBL3823873)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant human CYP2C9 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185307(CHEMBL3822473)
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of recombinant human CYP3A4 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185305(CHEMBL3822867)
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of recombinant human CYP2D6 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185305(CHEMBL3822867)
Affinity DataIC50: 2.29E+4nMAssay Description:Inhibition of recombinant human CYP3A4 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185305(CHEMBL3822867)
Affinity DataIC50: 3.18E+4nMAssay Description:Inhibition of recombinant human CYP2B6 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185306(CHEMBL3823873)
Affinity DataIC50: 3.57E+4nMAssay Description:Inhibition of recombinant human CYP2B6 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Palacky University In Olomouc

Curated by ChEMBL
LigandPNGBDBM50185307(CHEMBL3822473)
Affinity DataIC50: 3.62E+4nMAssay Description:Inhibition of recombinant human CYP2B6 by P450-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2017
Entry Details Article
PubMed