Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 7397
TargetInterleukin-10(Human)
Broad Institute

LigandPNGBDBM192713(HG-9-91-01 derivative, 2)
Affinity DataEC50:  3nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Broad Institute

LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataIC50: 3.5nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Broad Institute

LigandPNGBDBM192714(YKL-05-095 (3) | US11725011, Compound YKL-05-95)
Affinity DataIC50: 6nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetInterleukin-10(Human)
Broad Institute

LigandPNGBDBM192714(YKL-05-095 (3) | US11725011, Compound YKL-05-95)
Affinity DataEC50:  11nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Broad Institute

LigandPNGBDBM192713(HG-9-91-01 derivative, 2)
Affinity DataIC50: 19.5nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Broad Institute

LigandPNGBDBM192715(YKL-05-096 (4) | US11725011, Compound YKL-05-96)
Affinity DataIC50: 34nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Broad Institute

LigandPNGBDBM192716(YKL-05-099 (5) | US11725011, Compound YKL-05-99)
Affinity DataIC50: 40nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetInterleukin-10(Human)
Broad Institute

LigandPNGBDBM192715(YKL-05-096 (4) | US11725011, Compound YKL-05-96)
Affinity DataEC50:  70nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Broad Institute

LigandPNGBDBM192717(HG-9-91-01 derivative, 6)
Affinity DataIC50: 150nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetInterleukin-10(Human)
Broad Institute

LigandPNGBDBM192712(HG-9-91-01 (1))
Affinity DataEC50:  220nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetInterleukin-10(Human)
Broad Institute

LigandPNGBDBM192716(YKL-05-099 (5) | US11725011, Compound YKL-05-99)
Affinity DataEC50:  460nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
Broad Institute

LigandPNGBDBM192718(HG-9-91-01 derivative, 7)
Affinity DataIC50: 7.00E+3nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetInterleukin-10(Human)
Broad Institute

LigandPNGBDBM192717(HG-9-91-01 derivative, 6)
Affinity DataEC50: >1.00E+4nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed
TargetInterleukin-10(Human)
Broad Institute

LigandPNGBDBM192718(HG-9-91-01 derivative, 7)
Affinity DataEC50: >1.00E+4nMAssay Description:Concentration-dependent effects of HG-9-91-01 analogs on IL-10 release and cellular cytotoxicity in Zymosan A-stimulated BMDCs were measured using Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2016
Entry Details Article
PubMed