Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50047619
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataEC50:  2.10nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-2-imidazoline | 2-(2,6-dic...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Affinity DataEC50:  178nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50387827(CHEMBL2058635)
Affinity DataKi:  0.178nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50021809((2,6-Dichloro-4-iodo-phenyl)-imidazolidin-2-yliden...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50091345(CHEMBL2092861)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM81807(NSC_71310 | CAS_104054-27-5 | ATIPAMEZOLE)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50240366(2-Naphthalen-2-yl-4,5-dihydro-1H-imidazole | 2-(na...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50085683(4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole ...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179393(Efaroxan)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50019646(CHEMBL17860 | lofexidine | 2-(alpha-(2,6-Dichlorop...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50138500(2-((E)-Styryl)-4,5-dihydro-1H-imidazole | 2-styryl...)
Affinity DataKi:  19nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-2-imidazoline | 2-(2,6-dic...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179397(CHEMBL1162356)
Affinity DataKi:  28nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-2-imidazoline | 2-(2,6-dic...)
Affinity DataKi:  126nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50070328(CHEBI:8862 | Rilmenidine)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50412260(CHEMBL273485)
Affinity DataKi:  309nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179398(CHEMBL94022)
Affinity DataKi:  347nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179396(CHEMBL1907831)
Affinity DataKi:  589nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179395(CHEMBL14640)
Affinity DataKi:  708nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179391(CHEMBL3593723)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50019848(CHEMBL10316 | Idazoxan | US8633208, Idazoxan | 4,5...)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50138499(2-Phenethyl-4,5-dihydro-1H-imidazole | CHEMBL14210)
Affinity DataKi:  3.72E+3nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50091347(CHEMBL71429)
Affinity DataKi:  6.31E+3nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179394(CHEMBL68608)
Affinity DataKi:  7.24E+3nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179392(CHEMBL3593725)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179387(CHEMBL3814276)
Affinity DataKi:  2.70E+4nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179384(CHEMBL3814220)
Affinity DataKi:  4.10E+4nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179386(CHEMBL3814626)
Affinity DataKi:  5.20E+4nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179382(CHEMBL3814535)
Affinity DataKi:  5.80E+4nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179383(CHEMBL3814593)
Affinity DataKi:  6.20E+4nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179385(CHEMBL3814521)
Affinity DataKi:  8.00E+4nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179388(CHEMBL3814259)
Affinity DataKi:  9.90E+4nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179390(CHEMBL3815157)
Affinity DataKi:  1.10E+5nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50179389(CHEMBL3813724)
Affinity DataKi:  1.10E+5nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed