Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 7443
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195575((R)-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H-1...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195574((R)-(2-phenylpiperidin-1-yl)(3-(4-(pyridin-3-yl)ph...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195572((R)-N,N-dimethyl-4'-(2-(2-phenylpiperidine-1-c...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195581((2R,3R)-2-(3-ethynylphenyl)-1-(3-(4-(2-morpholinop...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195570((S)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195571((R)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50: 5nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195580((2R,3R)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl...)
Affinity DataIC50: 6nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195575((R)-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H-1...)
Affinity DataIC50: 7nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195573((R)-4'-(1-(2-phenylpiperidine-1-carbonyl)-1H-1...)
Affinity DataIC50: 7nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195578((2R, 4R)-1-(3-(4-(2-morpholinopyrimidin-5-yl)pheny...)
Affinity DataIC50: 11nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195572((R)-N,N-dimethyl-4'-(2-(2-phenylpiperidine-1-c...)
Affinity DataIC50: 21nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195574((R)-(2-phenylpiperidin-1-yl)(3-(4-(pyridin-3-yl)ph...)
Affinity DataIC50: 36nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195573((R)-4'-(1-(2-phenylpiperidine-1-carbonyl)-1H-1...)
Affinity DataIC50: 48nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195571((R)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50: 59nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195576(cis-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H...)
Affinity DataIC50: 710nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195579((2S,3S)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl...)
Affinity DataIC50: 1.10E+3nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195578((2R, 4R)-1-(3-(4-(2-morpholinopyrimidin-5-yl)pheny...)
Affinity DataIC50: 3.70E+3nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195577((2S,4S)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl...)
Affinity DataIC50: 6.50E+3nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
LigandPNGBDBM195570((S)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1...)
Affinity DataIC50: 1.60E+4nMpH: 7.5Assay Description:For determination of IC50 values for LYPLAL1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195577((2S,4S)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl...)
Affinity DataIC50: 1.90E+4nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195579((2S,3S)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl...)
Affinity DataIC50: 2.90E+4nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195576(cis-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H...)
Affinity DataIC50: 3.60E+4nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195580((2R,3R)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl...)
Affinity DataIC50: 5.00E+4nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Human)
Pfizer

LigandPNGBDBM195581((2R,3R)-2-(3-ethynylphenyl)-1-(3-(4-(2-morpholinop...)
Affinity DataIC50: 5.00E+4nMpH: 7.5Assay Description:For determination of IC50 values for CES1 inhibitors, the reactions were carried out in 1.5 mL microcentrifuge tubes in a total reaction volume of 25...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed