Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 7582
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit

LigandPNGBDBM203869(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)
Affinity DataKi:  0.900nM ΔG°:  -51.5kJ/mole IC50: 3.40nMpH: 7.4 T: 2°CAssay Description:Compound IC50 values were assessed following a 10-point, half-log10 dilution schema starting at 10 uM compound concentration. The assay was performed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit

LigandPNGBDBM203875(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)
Affinity DataKi:  1.20nM ΔG°:  -50.7kJ/mole IC50: 4.20nMpH: 7.4 T: 2°CAssay Description:Compound IC50 values were assessed following a 10-point, half-log10 dilution schema starting at 10 uM compound concentration. The assay was performed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit

LigandPNGBDBM203870(7-(3-((3-Acetyl-4-boronophenoxy)methyl)-1,5-dimeth...)
Affinity DataKi:  1.20nM ΔG°:  -50.7kJ/mole IC50: 4.70nMpH: 7.4 T: 2°CAssay Description:Compound IC50 values were assessed following a 10-point, half-log10 dilution schema starting at 10 uM compound concentration. The assay was performed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit

LigandPNGBDBM203876(Mcl-1 inhibitor 12)
Affinity DataKi:  1.60nM ΔG°:  -50.0kJ/mole IC50: 5.96nMpH: 7.4 T: 2°CAssay Description:Compound IC50 values were assessed following a 10-point, half-log10 dilution schema starting at 10 uM compound concentration. The assay was performed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit

LigandPNGBDBM203871(7-(3-((3-formylphenoxy)methyl)-1,5-dimethyl-1H-pyr...)
Affinity DataKi:  16nM ΔG°:  -44.3kJ/mole IC50: 59.5nMpH: 7.4 T: 2°CAssay Description:Compound IC50 values were assessed following a 10-point, half-log10 dilution schema starting at 10 uM compound concentration. The assay was performed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit

LigandPNGBDBM203873(7-(3-((4-Boronophenoxy)methyl)-1,5-dimethyl-1H-pyr...)
Affinity DataKi:  44nM ΔG°:  -41.8kJ/mole IC50: 162nMpH: 7.4 T: 2°CAssay Description:Compound IC50 values were assessed following a 10-point, half-log10 dilution schema starting at 10 uM compound concentration. The assay was performed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit

LigandPNGBDBM203872(7-(3-((3-Acetylphenoxy)methyl)-1,5-dimethyl-1H-pyr...)
Affinity DataKi:  64nM ΔG°:  -40.9kJ/mole IC50: 237nMpH: 7.4 T: 2°CAssay Description:Compound IC50 values were assessed following a 10-point, half-log10 dilution schema starting at 10 uM compound concentration. The assay was performed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Human)
Oncology Innovative Medicines Unit

LigandPNGBDBM203874(Mcl-1 inhibitor 10)
Affinity DataKi:  104nM ΔG°:  -39.7kJ/mole IC50: 383nMpH: 7.4 T: 2°CAssay Description:Compound IC50 values were assessed following a 10-point, half-log10 dilution schema starting at 10 uM compound concentration. The assay was performed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed