Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50011703
TargetRetinoic acid receptor RXR-alpha(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human RXR-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human LXR-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | [3H]T0901317 | T 0901317 | N-[4-(1,1...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human LXR-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PPAR-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50099491(cid_3392731 | CHEMBL21241 | 2-(4-{2-[3-Cyclohexyl-...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human PPAR-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PPAR-deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50127222({4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human PPAR-deltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PPAR-gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50085048((S)-2-(2-benzoylphenylamino)-3-(4-(2-(methyl(pyrid...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human PPAR-gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor subfamily 1 group I member 2(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50030477(CHEBI:77317 | SR-12813 | CHEMBL458767)
Affinity DataEC50:  60nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human CARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM31892(CHEMBL705 | 9-cis retinoic acid | alitretinoin | P...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human RXR-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetVitamin D3 receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human VDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human VDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human ERMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM17292([2,4,6,7-3H]-17beta-estradiol | [3H]-estradiol | 1...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human ERMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM8903(CHEMBL103 | (1S,2R,10S,11S,14S,15S)-14-acetyl-2,15...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human PRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human TRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50354850(BUDESONIDE | US10869929, Compound Budesonide | US1...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human GRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM53721(MLS000028461 | Urso 250 | ursodeoxycholicacid | (4...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM53721(MLS000028461 | Urso 250 | ursodeoxycholicacid | (4...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50:  140nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550153(CHEMBL4758363)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550154(CHEMBL4740844)
Affinity DataEC50:  4.70E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300201(3alpha,7alpha,12alpha-Trihydroxy-6alpha-ethyl-5bet...)
Affinity DataEC50:  7.00E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550155(CHEMBL4740500)
Affinity DataEC50:  600nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550156(CHEMBL4790262)
Affinity DataEC50:  400nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  3.30E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550153(CHEMBL4758363)
Affinity DataEC50:  4.15E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550154(CHEMBL4740844)
Affinity DataEC50:  6.20E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300201(3alpha,7alpha,12alpha-Trihydroxy-6alpha-ethyl-5bet...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550155(CHEMBL4740500)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550156(CHEMBL4790262)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 3(Human)
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human CARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed