Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 50000394
TargetTyrosine-protein kinase BTK(Human)
Intellisyn Pharma

Curated by ChEMBL
LigandPNGBDBM50249031(CHEMBL4093436)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant full length BTK (unknown origin) using peptide substrate by capillary elctrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1(Human)
Intellisyn Pharma

Curated by ChEMBL
LigandPNGBDBM86283(N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-py...)
Affinity DataEC50:  79nMAssay Description:Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibitio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMuscarinic acetylcholine receptor M2(Human)
Intellisyn Pharma

Curated by ChEMBL
LigandPNGBDBM50249030(CHEMBL3770346)
Affinity DataKi:  158nMAssay Description:Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-in-CHO cell membranes in presence of mAChR2 agonist xanomeline after 90 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Intellisyn Pharma

Curated by ChEMBL
LigandPNGBDBM50249030(CHEMBL3770346)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H]NMS from wild-type human mAChR2 expressed in Flp-In-CHO cell membranes in presence of mAChR2 agonist acetylcholine after 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
Intellisyn Pharma

Curated by ChEMBL
LigandPNGBDBM50249032(CHEBI:28645 | Dietade Dietary Foods | Fructose | L...)
Affinity DataEC50:  1.26E+4nMAssay Description:Positive allosteric modulatory activity at recombinant human glycine alpha1 receptor expressed in HEK293 cells assessed as potentiation of glycine-in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2019
Entry Details Article
PubMed