Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50001504
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282224(CHEMBL4172856)
Affinity DataKd:  38nMAssay Description:Binding affinity to full length C-terminal FLAG tagged human SMS2 expressed in HEK293 cells after 120 mins by AS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282224(CHEMBL4172856)
Affinity DataKd:  240nMAssay Description:Binding affinity to full length C-terminal FLAG tagged human SMS2 S217A mutant expressed in HEK293 cells after 120 mins by AS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282224(CHEMBL4172856)
Affinity DataKd: >3.00E+3nMAssay Description:Binding affinity to full length C-terminal FLAG tagged human SMS2 S227A mutant expressed in HEK293 cells after 120 mins by AS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282224(CHEMBL4172856)
Affinity DataKd: >3.00E+3nMAssay Description:Binding affinity to full length C-terminal FLAG tagged human SMS2 H229A mutant expressed in HEK293 cells after 120 mins by AS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282224(CHEMBL4172856)
Affinity DataKd:  30nMAssay Description:Binding affinity to full length C-terminal FLAG tagged human SMS2 H272A mutant expressed in HEK293 cells after 120 mins by AS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282224(CHEMBL4172856)
Affinity DataKd:  28nMAssay Description:Binding affinity to full length C-terminal FLAG tagged human SMS2 D276A mutant expressed in HEK293 cells after 120 mins by AS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282224(CHEMBL4172856)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of full length C-terminal FLAG tagged human SMS2 expressed in HEK293 cell membranes using DMPC-d72 and C17-ceramide as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282208(CHEMBL4177314)
Affinity DataIC50: 16nMAssay Description:Inhibition of full length C-terminal FLAG tagged human SMS2 expressed in HEK293 cell membranes using DMPC-d72 and C17-ceramide as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282210(CHEMBL4162182)
Affinity DataIC50: 410nMAssay Description:Inhibition of human SMS2 expressed in HEK293T cells using C2-ceramide as substrate preincubated for 60 mins followed by substrate addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282210(CHEMBL4162182)
Affinity DataIC50: 470nMAssay Description:Inhibition of full length C-terminal FLAG tagged human SMS2 expressed in HEK293 cell membranes using DMPC-d72 and C17-ceramide as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282210(CHEMBL4162182)
Affinity DataIC50: 950nMAssay Description:Inhibition of human SMS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282224(CHEMBL4172856)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length C-terminal FLAG tagged human SMS1 expressed in HEK293 cell membranes using DMPC-d72 and C17-ceramide as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282210(CHEMBL4162182)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of full length C-terminal FLAG tagged human SMS2 expressed in HEK293 cell membranes using DMPC-d72 and C17-ceramide as substrate after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282208(CHEMBL4177314)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of full length C-terminal FLAG tagged human SMS1 expressed in HEK293 cell membranes using DMPC-d72 and C17-ceramide as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282209(CHEMBL1161894)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of full length C-terminal FLAG tagged human SMS2 expressed in HEK293 cell membranes using DMPC-d72 and C17-ceramide as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282209(CHEMBL1161894)
Affinity DataIC50: 8.60E+4nMAssay Description:Inhibition of full length C-terminal FLAG tagged human SMS1 expressed in HEK293 cell membranes using DMPC-d72 and C17-ceramide as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50282210(CHEMBL4162182)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SMS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed