Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50000064
TargetDNA polymerase alpha catalytic subunit(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50090910(6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM294045(US10106571, Example 2 | US10106571, Example 23)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of human CYP3A4 using ketoconazole as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human CYP3A4 using ketoconazole as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetDNA polymerase beta(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50020676(CHEMBL566812 | CHEBI:41846)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human DNA polymerase beta using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50239939(CHEMBL4088430)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM294045(US10106571, Example 2 | US10106571, Example 23)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human CYP2C9 using sulfaphenazole as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human CYP2C9 using sulfaphenazole as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetDNA polymerase beta(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50239939(CHEMBL4088430)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DNA polymerase beta using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetDNA polymerase beta(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DNA polymerase beta using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM294045(US10106571, Example 2 | US10106571, Example 23)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP1A2 using alpha-naphthoflavone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM294045(US10106571, Example 2 | US10106571, Example 23)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6 using quinidine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6 using quinidine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetDNA polymerase alpha catalytic subunit(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP1A2 using alpha-naphthoflavone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2019
Entry Details Article
PubMed