Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with all data for entry = 50002545
TargetGlycine receptor subunit alpha-1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  32nMAssay Description:Positive allosteric modulation of human glycine alpha1 receptor expressed in HEK293T cells assessed as glycine-induced increase incurrent response af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50459889(CHEMBL4224740)
Affinity DataEC50:  7.60E+3nMAssay Description:Positive allosteric modulation of recombinant wild type GABAA receptor alpha2beta2gamma2S (unknown origin) expressed in HEK293 cells assessed as pote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459891(CHEMBL4229086)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at GABAA receptor in Sprague-Dawley rat forebrain membranes assessed as enhancement of [3H]muscimol binding after 2 hrs by radiometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50: >5.00E+4nMAssay Description:Positive allosteric modulation of C57BL/6 mouse GABAA receptor alpha1beta2gamma2 assessed as increase in GABA-induced current response at -60 mV hold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as glycine-induced increase in current response a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459895(CHEMBL1314103)
Affinity DataEC50:  3.90E+3nMAssay Description:Positive allosteric modulation of recombinant human glycine receptor alpha3 expressed in CHOK1 cells at -60 mV holding potential by whole cell patch-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459893(Gelsemine)
Affinity DataEC50:  590nMAssay Description:Positive allosteric modulation of recombinant human glycine receptor alpha1 expressed in HEK293 cells assessed as increase in glycine-induced current...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459890(CHEBI:70620 | Bromophene)
Affinity DataEC50:  320nMAssay Description:Agonist activity at recombinant human GABAA receptor alpha1beta1gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataEC50:  163nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta2delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459890(CHEBI:70620 | Bromophene)
Affinity DataEC50:  720nMAssay Description:Agonist activity at recombinant human GABAA receptor alpha1beta2gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycine receptor subunit alpha-3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  454nMAssay Description:Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as glycine-induced increase in current response a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at 5-HT3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459889(CHEMBL4224740)
Affinity DataEC50:  1.77E+4nMAssay Description:Positive allosteric modulation of recombinant wild type GABAA receptor alpha3beta2gamma2S (unknown origin) expressed in HEK293 cells assessed as pote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  327nMAssay Description:Positive allosteric modulation of human glycine alpha1 receptor expressed in HEK293T cells assessed as glycine-induced increase incurrent response af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  66nMAssay Description:Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of C57BL/6 mouse GABAA receptor alpha1beta3gamma2 assessed as increase in GABA-induced current response at -60 mV hold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459884(CHEMBL4228846)
Affinity DataEC50:  237nMAssay Description:Positive allosteric modulation of human alpha4beta4 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidine hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  330nMAssay Description:Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459884(CHEMBL4228846)
Affinity DataEC50:  275nMAssay Description:Positive allosteric modulation of human (alpha4beta2)2beta2 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459884(CHEMBL4228846)
Affinity DataEC50:  660nMAssay Description:Positive allosteric modulation of human alpha2beta2 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidine hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50053615(m-chlorophenylbiguanidine | 3-Chloro-Phenyl biguan...)
Affinity DataEC50:  2.80E+3nMAssay Description:Agonist activity at human 5-HT43AB receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50053615(m-chlorophenylbiguanidine | 3-Chloro-Phenyl biguan...)
Affinity DataEC50:  3.80E+3nMAssay Description:Agonist activity at human 5-HT43A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459890(CHEBI:70620 | Bromophene)
Affinity DataEC50:  1.08E+3nMAssay Description:Agonist activity at recombinant human GABAA receptor alpha2beta2gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataEC50:  374nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459884(CHEMBL4228846)
Affinity DataEC50:  446nMAssay Description:Positive allosteric modulation of human alpha4beta2 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidine hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459884(CHEMBL4228846)
Affinity DataEC50:  286nMAssay Description:Positive allosteric modulation of human alpha2beta4 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidine hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  171nMAssay Description:Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459883(CHEMBL4228983)
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant human 5-HT3A receptor expressed in HEK293 cell membranes using 5-HT as substrate in presence of [3H]GR65630More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459888(CHEMBL4225157)
Affinity DataIC50: 320nMAssay Description:Inhibition of human alpha7 nAChR expressed in Xenopus oocytes at -80 mV holding potential by electro-physiological analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459885(CHEMBL1382868)
Affinity DataIC50: 430nMAssay Description:Inhibition of human 5-HT3AB receptor expressed in transient A201 cells after 30 mins by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459885(CHEMBL1382868)
Affinity DataIC50: 620nMAssay Description:Inhibition of human 5-HT3A receptor expressed in transient A201 cells after 30 mins by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3E(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459885(CHEMBL1382868)
Affinity DataIC50: 710nMAssay Description:Inhibition of human 5-HT3AE receptor expressed in transient A201 cells after 30 mins by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3C(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459885(CHEMBL1382868)
Affinity DataIC50: 840nMAssay Description:Inhibition of human 5-HT3AC receptor expressed in transient A201 cells after 30 mins by Fluo-4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459888(CHEMBL4225157)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at 5-HT3A receptor (unknown origin) assessed as inhibition of serotonin-induced peak currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459883(CHEMBL4228983)
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at rat brain membrane alpha7 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-2/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459893(Gelsemine)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human glycine receptor alpha2beta expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of C57BL/6 mouse GABAA receptor alpha1beta3gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 5-HT3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1/beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459893(Gelsemine)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human glycine receptor alpha1beta expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGlycine receptor subunit beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459893(Gelsemine)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human glycine receptor alpha3beta expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459894(CHEBI:17580 | Linalool)
Affinity DataIC50: 1.41E+5nMAssay Description:Inhibition of human 5-HT3A receptor expressed in Xenopus laevis oocytes assessed as HT-induced current by electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459887(Cineole | Eucalyptol | FEMA NO. 2465 | NSC-6171)
Affinity DataIC50: 2.57E+5nMAssay Description:Inhibition of human 5-HT3A receptor expressed in Xenopus laevis oocytes assessed as HT-induced current by electrophysiological methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50459886(CHEMBL261010)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [3H]granisetron from human 5-HT3A receptor expressed in HEK293 cells by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459882(CHEMBL4060185)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]Ro15-1788 from human GABAA receptor alpha3beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459882(CHEMBL4060185)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]Ro15-1788 from human GABAA receptor alpha1beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459882(CHEMBL4060185)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]Ro15-1788 from human GABAA receptor alpha5beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50459882(CHEMBL4060185)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]Ro15-1788 from human GABAA receptor alpha6beta3gamma2 expressed in LTK cells preincubated for 30 secs measured every 15 mins at -...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
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