Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50000250
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST fused human recombinant JAK1 (866 to 1154 amino acids) expressed in insect cells using ATP and peptide substrate (FITC-C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264229((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal GST fused human recombinant JAK1 (866 to 1154 amino acids) expressed in insect cells using ATP and peptide substrate (FITC-C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264242((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal GST fused human recombinant JAK1 (866 to 1154 amino acids) expressed in insect cells using ATP and peptide substrate (FITC-C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal GST fused human recombinant JAK1 (866 to 1154 amino acids) expressed in insect cells using ATP and peptide substrate (FITC-C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)
Affinity DataIC50: 57nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)
Affinity DataIC50: 58nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264229((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Affinity DataIC50: 75nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264242((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Affinity DataIC50: 104nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)
Affinity DataIC50: 322nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK2 (831 to 1132 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Affinity DataIC50: 643nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Affinity DataIC50: 847nMAssay Description:Inhibition of N-terminal GST fused human recombinant JAK1 (866 to 1154 amino acids) expressed in insect cells using ATP and peptide substrate (FITC-C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK2 (831 to 1132 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264229((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK2 (831 to 1132 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264188((2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264242((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK2 (831 to 1132 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264188((2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of N-terminal GST fused human recombinant JAK1 (866 to 1154 amino acids) expressed in insect cells using ATP and peptide substrate (FITC-C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK3 (781 to 1124 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264188((2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK3 (781 to 1124 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK2 (831 to 1132 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264242((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK3 (781 to 1124 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264188((2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK2 (831 to 1132 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK3 (781 to 1124 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264229((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK3 (781 to 1124 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK3 (781 to 1124 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed