Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50000600
TargetMitogen-activated protein kinase 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50254739(CHEMBL4079223)
Affinity DataKd:  16nMAssay Description:Binding affinity to full length wild type human ERK2 (M1 to P379 residues) expressed in bacterial expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50254740(CHEMBL4104378)
Affinity DataKd:  500nMAssay Description:Binding affinity to C-terminal FLAG-tagged human ERK2 expressed in Escherichia coli (DE3) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50254741(CHEMBL4072127)
Affinity DataKd:  1.80E+4nMAssay Description:Binding affinity to non-phosphorylated full length N-terminal His6-tagged/SUMO-fused ERK2 (1 to 360 residues) (unknown origin) by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50254739(CHEMBL4079223)
Affinity DataKd: >2.50E+3nMAssay Description:Binding affinity to full length wild type human GSK3beta (M1 to T433 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50254742(CHEMBL4076347)
Affinity DataIC50: 14nMAssay Description:Binding affinity to non-phosphorylated full length N-terminal His6-tagged/SUMO-fused ERK2 (1 to 360 residues) (unknown origin) by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50254739(CHEMBL4079223)
Affinity DataIC50: 25nMAssay Description:Inhibition of phosphorylated ERK2 (unknown origin) using myelin basic protein as substrate after 2 hrs in presence of ATP by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50254743(CHEMBL4098959)
Affinity DataIC50: 700nMAssay Description:Binding affinity to non-phosphorylated full length N-terminal His6-tagged/SUMO-fused ERK2 (1 to 360 residues) (unknown origin) by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50229978(5-(2-phenylH-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyraz...)
Affinity DataIC50: 1.20E+3nMAssay Description:Binding affinity to non-phosphorylated full length N-terminal His6-tagged/SUMO-fused ERK2 (1 to 360 residues) (unknown origin) by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50254770(CHEMBL4098700)
Affinity DataIC50: 1.23E+4nMAssay Description:Binding affinity to non-phosphorylated full length N-terminal His6-tagged/SUMO-fused ERK2 (1 to 360 residues) (unknown origin) by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed