Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50000814
LigandPNGBDBM50398668(CHEMBL2178134 | US8802674, 256)
Affinity DataIC50: 97nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50398668(CHEMBL2178134 | US8802674, 256)
Affinity DataIC50: 97nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM223552(US9321748, 12)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223552(US9321748, 12)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223553(US9321748, 13)
Affinity DataIC50: 340nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223553(US9321748, 13)
Affinity DataIC50: 340nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223554(US9321748, 14)
Affinity DataIC50: 340nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223546(US9321748, 6)
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223546(US9321748, 6)
Affinity DataIC50: 490nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223549(US9321748, 9)
Affinity DataIC50: 540nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223549(US9321748, 9)
Affinity DataIC50: 550nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223554(US9321748, 14)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223541(US9321748, 1)
Affinity DataIC50: 910nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223552(US9321748, 12)
Affinity DataIC50: 920nMAssay Description:Inhibition LRRK2 G2019S mutant (unknown origin) Ser935 phosphorylation in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223543(US9321748, 3)
Affinity DataIC50: 970nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223543(US9321748, 3)
Affinity DataIC50: 970nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223542(US9321748, 2)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223542(US9321748, 2)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM223552(US9321748, 12)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition wild type LRRK2 (unknown origin) Ser935 phosphorylation in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50260922(CHEMBL4060747)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50260922(CHEMBL4060747)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50470161(CHEMBL4091112)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50470158(CHEMBL4103716)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50470157(CHEMBL4098856)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50260924(CHEMBL4104344)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50470160(CHEMBL4069384)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50260923(CHEMBL4092594)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50260923(CHEMBL4092594)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50470156(CHEMBL4100328)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50470159(CHEMBL4096615)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50260924(CHEMBL4104344)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50260925(CHEMBL4095694)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50260925(CHEMBL4095694)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50470162(CHEMBL4064894)
Affinity DataIC50: 5.70E+4nMAssay Description:Inhibition of recombinant human LRRK2 (970 to 2527 residues) G2019S mutant expressed in baculovirus preincubated for 30 mins followed by fluorescein-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2020
Entry Details Article
PubMed