Compile Data Set for Download or QSAR
Report error Found 85 Enz. Inhib. hit(s) with all data for entry = 50000609
TargetInterstitial collagenase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254802(CHEMBL4088630)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254802(CHEMBL4088630)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of MMP8 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254802(CHEMBL4088630)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254802(CHEMBL4088630)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MMP9 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetCollagenase 3(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MMP13 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50139181(2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HMG-CoA reductase (unknown origin) using [14C]-HMG-CoA as substrate after 5 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetCollagenase 3(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082555(4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-car...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP13 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetCollagenase 3(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254802(CHEMBL4088630)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP13 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50089619(9-(3,4-Dimethoxy-phenyl)-4a,12a-dihydroxy-4,4,6a,1...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human erythrocyte AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of MMP8 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254802(CHEMBL4088630)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of MMP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetCollagenase 3(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254789(CHEMBL4067375)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MMP13 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082538((S)-4-(4-Methoxy-benzenesulfonyl)-2,2-dimethyl-1,1...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MMP9 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetCollagenase 3(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082538((S)-4-(4-Methoxy-benzenesulfonyl)-2,2-dimethyl-1,1...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of MMP13 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM34168(cid_53232 | SMR000058779 | MLS000069585 | LOVASTAT...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of HMG-CoA reductase (unknown origin) using [14C]-HMG-CoA as substrate after 5 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254788(CHEMBL4088701)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of HMG-CoA reductase (unknown origin) using [14C]-HMG-CoA as substrate after 5 mins in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254786(CHEMBL4102322)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human GP2b/3a interaction with human fibrinogen after 3 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082538((S)-4-(4-Methoxy-benzenesulfonyl)-2,2-dimethyl-1,1...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of MMP8 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254783(CHEMBL4092042)
Affinity DataKi:  2.5nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in mouse NIH/3T3 cells assessed as induction of IP3 formation after 0.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254782(CHEMBL4086240)
Affinity DataKi:  2.5nMAssay Description:Agonist activity at human 5-HT2C receptor expressed in mouse NIH/3T3 cells assessed as induction of IP3 formation after 0.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of MMP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066659(1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-H...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of MMP9 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082538((S)-4-(4-Methoxy-benzenesulfonyl)-2,2-dimethyl-1,1...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of MMP9 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066657(1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyri...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of MMP9 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254789(CHEMBL4067375)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50001859(BUSPAR | CHEMBL49 | 8-[4-(4-Pyrimidin-2-yl-piperaz...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to 5-HT1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStromelysin-1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082538((S)-4-(4-Methoxy-benzenesulfonyl)-2,2-dimethyl-1,1...)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082538((S)-4-(4-Methoxy-benzenesulfonyl)-2,2-dimethyl-1,1...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of MMP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50104844(N-[(1R,3R)-3-(2,3-Dihydro-benzofuran-4-yl)-2,2-dim...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human NHE1 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254813(CHEMBL4096340)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human GST-tagged IGF-1R (950 to 133 residues) expressed in baculovirus after 5 mins in presence of [gamma33P]-ATP by top count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082555(4-(4-Methoxy-benzenesulfonyl)-thiomorpholine-3-car...)
Affinity DataIC50: 15nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066659(1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-H...)
Affinity DataIC50: 18nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Bovine)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50038001(CHEMBL1166 | (2R,4S)-1-[5-Guanidino-2-(3-methyl-1,...)
Affinity DataKi:  20nMAssay Description:Inhibition of bovine plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50092119((1-{3-[2-Fluoro-4-(imino-thiazolidin-3-yl-methyl)-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of GP2b/3a in human platelet-rich plasma assessed as reduction in collagen-induced platelet aggregation preincubated for 1 min followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrilysin(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254802(CHEMBL4088630)
Affinity DataIC50: 23nMAssay Description:Inhibition of MMP7 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066659(1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-H...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human interstitial recombinant N-terminal MMP1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-beta(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at RXRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-gamma(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at RXRgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMatrilysin(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 30nMAssay Description:Inhibition of MMP7 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrilysin(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066659(1,3-BIS-(4-METHOXY-BENZENESULFONYL)-5,5-DIMETHYL-H...)
Affinity DataIC50: 30nMAssay Description:Inhibition of MMP7 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetProthrombin(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254781(CHEMBL4083414)
Affinity DataKi:  30nMAssay Description:Inhibition of human plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50005132(4,4-Dimethyl-1-[4-(4-pyrimidin-2-yl-piperazin-1-yl...)
Affinity DataKi:  32nMAssay Description:Binding affinity to 5-HT1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50066657(1,3-Bis-(4-methoxy-benzenesulfonyl)-hexahydro-pyri...)
Affinity DataIC50: 33nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at RXRaplha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50038001(CHEMBL1166 | (2R,4S)-1-[5-Guanidino-2-(3-methyl-1,...)
Affinity DataKi:  40nMAssay Description:Inhibition of human plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetProthrombin(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50254811(CHEMBL4091198)
Affinity DataKi:  40nMAssay Description:Inhibition of human plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetMatrilysin(Human)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50082538((S)-4-(4-Methoxy-benzenesulfonyl)-2,2-dimethyl-1,1...)
Affinity DataIC50: 41nMAssay Description:Inhibition of MMP7 (unknown origin) expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 20 to 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
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