Compile Data Set for Download or QSAR
Report error Found 75 Enz. Inhib. hit(s) with all data for entry = 50002722
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataKd: <1nMAssay Description:Binding affinity to human factor D by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462096(CHEMBL4247287)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to C3 derived from human plasma by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462101(CHEMBL4241221)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to C3b derived from human plasma by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462106(CHEMBL3736108)
Affinity DataEC50:  7nMAssay Description:Agonist activity at C3aR in HMDM assessed as induction of Ca2+ release measured for 5 mins by Fluo-3 AM dye-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462105(CHEMBL4239035)
Affinity DataEC50:  15nMAssay Description:Agonist activity at C3aR in HMDM assessed as induction of Ca2+ releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human U937 cells assessed as inhibition of recombinant human C5a-induced cell degranulation preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor B(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM251408(US9452990, 90)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human factor B expressed in drosophila cells assessed as decrease in C3a formation using CVF-Bb complex and human complemen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human blood granulocytes assessed as inhibition of recombinant human C5a-induced CD11b expression on granulocytes pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human HL60 cells assessed as inhibition of recombinant human C5a-induced oxidative burst after 30 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human neutrophils assessed as inhibition of recombinant human C5a-induced chemotaxis preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human U937 cells assessed as inhibition of recombinant human C5a-induced chemotaxis preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human U937 cells assessed as inhibition of recombinant human C5a-induced intracellular calcium mobilization preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462093(CHEMBL4245250)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human C5aR1 expressed in Sf9 insect cell membranes co-expressing G-alphai2,G-beta1 and G-gamma2 assessed as inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50201566(CHEMBL2220483)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human C1s esterolytic activity using benzyloxycarbonyl-Lys-thiobenzyl as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462086(CHEMBL1628668)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at C5aR1 in human neutrophils assessed as inhibition of 0.1 nM recombinant human C5a-induced intracellular calcium releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462086(CHEMBL1628668)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at C5aR1 in HMDM assessed as inhibition of 1 nM recombinant human C5a-induced intracellular calcium release preincubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of factor D in human serum assessed as decrease in C3 deposition on PNH erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462108(CHEMBL4246585)
Affinity DataIC50: 4nMAssay Description:Inhibition of human factor D expressed in Escherichia coli using CVF-FB as substrate assessed as decrease in formation of factor B cleavage product B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of factor D in human serum assessed as decrease in alternative pathway of complement-mediated hemolysis of PNH erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human factor D using C3b as substrate assessed as decrease in formation of factor B cleavage product BaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50111445((S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methy...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at C5aR1 in HMDMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462107(CHEMBL4249566)
Affinity DataIC50: 23nMAssay Description:Displacement of Cy5 from recombinant human biotin labeled factor D expressed in Escherichia coli after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor B(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462112(CHEMBL4247942)
Affinity DataIC50: 23nMAssay Description:Displacement of Cy5 from recombinant human biotin-labeled factor B expressed in drosophila cells after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 28nMAssay Description:Antagonist activity at human C3aR expressed in RBL-2H3 cells assessed as inhibition of C3a-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human serum C1s using AGLME as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor B(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM251882(US9475806, 12-D)
Affinity DataIC50: 30nMAssay Description:Displacement of Cy5 from recombinant human biotin-labeled factor B expressed in drosophila cells after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50111445((S)-N-((3R,6S,9S,15S,20aS)-6-((1H-indol-3-yl)methy...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at C5aR1 in human PMNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM171268(US9085555, 698)
Affinity DataIC50: 30nMAssay Description:Inhibition of human factor D using CVF-FB as substrate assessed as decrease in formation of factor B cleavage product Ba by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMannan-binding lectin serine protease 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462102(CHEMBL4240381)
Affinity DataIC50: 40nMAssay Description:Inhibition of MASP-1-mediated C3 deposition in human serum after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMannan-binding lectin serine protease 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462088(CHEMBL4250967)
Affinity DataIC50: 42nMAssay Description:Inhibition of MASP1 (unknown origin)-induced lectin pathway by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50201566(CHEMBL2220483)
Affinity DataIC50: 46nMAssay Description:Inhibition of human serum C1s-mediated lysis of rabbit Ab-sensitized sheep erythrocytes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462095(CHEMBL4239466)
Affinity DataIC50: 50nMAssay Description:Displacement of 125I-C3a from recombinant human C3aR expressed in HEK293 cell membranes after 3 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462096(CHEMBL4247287)
Affinity DataIC50: 62nMAssay Description:Inhibition of C3 in human serum by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMannan-binding lectin serine protease 2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462098(CHEMBL4242955)
Affinity DataIC50: 66nMAssay Description:Inhibition of MASP2 (unknown origin)-induced lectin pathway by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM171268(US9085555, 698)
Affinity DataIC50: 70nMAssay Description:Inhibition of factor D in human serum assessed as decrease in lysis of human erythrocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM171268(US9085555, 698)
Affinity DataIC50: 70nMAssay Description:Inhibition of factor D in human serum assessed as decrease in C3 deposition on human erythrocytes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50201566(CHEMBL2220483)
Affinity DataIC50: 96nMAssay Description:Inhibition of human factor D esterolytic activity using benzyloxycarbonyl-Lys-thiobenzyl as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Rat)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462091(CHEMBL4241950)
Affinity DataIC50: 100nMAssay Description:Inhibition of factor D in zymogen-activated rat serum assessed as decrease in human erythrocyte lysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Rat)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462089(CHEMBL4243237)
Affinity DataIC50: 100nMAssay Description:Inhibition of factor D in zymogen-activated rat serum assessed as decrease in human erythrocyte lysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462091(CHEMBL4241950)
Affinity DataIC50: 100nMAssay Description:Inhibition of factor D in zymogen-activated human serum assessed as decrease in human erythrocyte lysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462089(CHEMBL4243237)
Affinity DataIC50: 100nMAssay Description:Inhibition of factor D in zymogen-activated human serum assessed as decrease in human erythrocyte lysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-M/beta-2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462087(CHEMBL4243248)
Affinity DataIC50: 140nMAssay Description:Inhibition of C3bi-AP binding to CR3 derived from human PMNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor D(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM171268(US9085555, 698)
Affinity DataIC50: 144nMAssay Description:Inhibition of factor D in human plasma assessed as decrease in alternative pathway-mediated MAC formation preincubated for 30 mins measured after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 200nMAssay Description:Displacement of 125I-C3a from human C3aR expressed in RBL-2H3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMannan-binding lectin serine protease 1(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462099(CHEMBL4246684)
Affinity DataIC50: 220nMAssay Description:Inhibition of MASP-1-mediated C3 deposition in human serum after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMannan-binding lectin serine protease 2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462102(CHEMBL4240381)
Affinity DataIC50: 230nMAssay Description:Inhibition of MASP-2-mediated C4 deposition in human serum after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement factor B(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462109(CHEMBL4244153)
Affinity DataIC50: 250nMAssay Description:Inhibition of human factor B-induced cleavage of C3 after 3 hrs by coomassie brilliant blue staining-based gel electrophoresisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462104(CHEMBL4248716)
Affinity DataIC50: 320nMAssay Description:Antagonist activity at C3aR in HMDM assessed as inhibition of agonist-induced Ca2+ releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetComplement C2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50462097(CHEMBL4247125)
Affinity DataIC50: 330nMAssay Description:Competitive/reversible inhibition of human C2 using Ac-SHLGLAR-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-M/beta-2(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM75309(cid_5709759 | SMR000718614 | MLS001032120 | (2Z)-3...)
Affinity DataIC50: 330nMAssay Description:Inhibition of C3bi-AP binding to CR3 derived from human PMNMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
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