Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50035745
TargetDihydrofolate reductase(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020099(CHEMBL283062 | 2-{4-[(2,4-Diamino-pteridin-6-ylmet...)
Affinity DataIC50: 23nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 25nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50367055(4-Aminofolic acid | 4-Aminopteroic acid | Aminopte...)
Affinity DataIC50: 25nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020100(CHEMBL26326 | 2-{4-[(2,4-Diamino-pteridin-6-ylmeth...)
Affinity DataIC50: 26nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020098(CHEMBL28112 | 2-{4-[(2,4-Diamino-pteridin-6-ylmeth...)
Affinity DataIC50: 29nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020097(CHEMBL25923 | 2-{4-[(2,4-Diamino-pteridin-6-ylmeth...)
Affinity DataIC50: 32nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020106(CHEMBL27306 | 2-{4-[(2,4-Diamino-pteridin-6-ylmeth...)
Affinity DataIC50: 34nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020104(CHEMBL275229 | 2-{4-[(2,4-Diamino-pteridin-6-ylmet...)
Affinity DataIC50: 67nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020103(CHEMBL26148 | 2-{4-[(2,4-Diamino-pteridin-6-ylmeth...)
Affinity DataIC50: 81nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020105(CHEMBL434004 | 2-{4-[(2,4-Diamino-pteridin-6-ylmet...)
Affinity DataIC50: 540nMAssay Description:Tested for inhibition against purified Dihydrofolate reductase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020107(CHEMBL281656 | 5-Amino-2-{4-[(2,4-diamino-pteridin...)
Affinity DataKi:  300nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020107(CHEMBL281656 | 5-Amino-2-{4-[(2,4-diamino-pteridin...)
Affinity DataKi:  300nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020101(CHEMBL281024 | 2-{4-[(2,4-Diamino-pteridin-6-ylmet...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020102(CHEMBL28049 | 5-Amino-2-{4-[(2,4-diamino-pteridin-...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020102(CHEMBL28049 | 5-Amino-2-{4-[(2,4-diamino-pteridin-...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020108(CHEMBL431290 | 5-Amino-2-{4-[(2-amino-4-hydroxy-pt...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from hogMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020101(CHEMBL281024 | 2-{4-[(2,4-Diamino-pteridin-6-ylmet...)
Affinity DataKi:  8.40E+3nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from mouseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020109(CHEMBL25870 | 2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hex...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from hogMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020102(CHEMBL28049 | 5-Amino-2-{4-[(2,4-diamino-pteridin-...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase obtained from ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50020099(CHEMBL283062 | 2-{4-[(2,4-Diamino-pteridin-6-ylmet...)
Affinity DataKi:  3.20E+5nMAssay Description:Inhibitory constant against purified Folyl-polyglutamate synthase from mouse liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed