Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50001416
TargetTransient receptor potential cation channel subfamily M member 2(Human)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM27497(2-Dimethylamino-N-(6-oxo-5,6-dihydro-phenanthridin...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux pretreated for 30 se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
TargetPhospholipase A2(Honeybee)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50242184(Scalaradial)
Affinity DataIC50: 70nMAssay Description:Inhibition of bee venom PLA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 2(Human)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50242184(Scalaradial)
Affinity DataIC50: 210nMAssay Description:Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux after 30 to 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 2(Rat)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50242184(Scalaradial)
Affinity DataIC50: 330nMAssay Description:Inhibition of TRPM2 in rat INS-1 cells assessed as reduction in ADPR-induced intracellular calcium flux measured after 60 mins by whole cell patch cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 2(Human)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM27502(CHEMBL127336 | 3,4-dihydro-5-(4-(1-piperidinyl)but...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human FLAG-tagged TRPM2 expressed in HEK293 cells assessed as reduction in H2O2-induced intracellular calcium flux pretreated for 30 se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 7(Mouse)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50242184(Scalaradial)
Affinity DataIC50: 760nMAssay Description:Inhibition of mouse FLAG-tagged TRPM7 expressed in HEK293 cells assessed as reduction in BAPTA-induced intracellular calcium flux after 15 to 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 2(Human)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50278349(2-(Diphenylboryloxy)Ethanamine | 2-Aminoethoxydiph...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux by whole cell patch clamp electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily M member 2(Human)
Queen'S Center For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50227083(CHEMBL173443)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human TRPM2 expressed in HEK293 cells assessed as reduction in ADPR-induced intracellular calcium flux at 0 mV holding potential by who...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed