Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50002044
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50452630(CHEMBL4203412)
Affinity DataKd:  5.90E+3nMAssay Description:Inhibition of fluorescein-labeled m7GDPC4H5 binding to mouse eIF4E (28 to 217 residues) by MST methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316304(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  2.00E+3nMAssay Description:Inhibition of fluorescein-labeled m7GDPC4H5 binding to mouse eIF4E (28 to 217 residues) by MST methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human DCPS using m7GMPF as substrate after 30 mins by nucleoside 5'-fluorophosphate probe based HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316304(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataIC50: 4.22E+4nMAssay Description:Inhibition of human DCPS using m7GMPF as substrate after 30 mins by nucleoside 5'-fluorophosphate probe based HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target7-methylguanosine phosphate-specific 5'-nucleotidase(Human)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50452630(CHEMBL4203412)
Affinity DataIC50: 8.78E+4nMAssay Description:Inhibition of recombinant His6/SUMO-tagged human cN3B (1 to 300 residues) expressed in Escherichia coli BL21(DE3) RIL assessed as reduction in dephos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target7-methylguanosine phosphate-specific 5'-nucleotidase(Human)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50452630(CHEMBL4203412)
Affinity DataIC50: 1.28E+5nMAssay Description:Inhibition of recombinant His6/SUMO-tagged human cN3B (1 to 300 residues) expressed in Escherichia coli BL21(DE3) RIL assessed as reduction in dephos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Targetm7GpppX diphosphatase(Human)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50452630(CHEMBL4203412)
Affinity DataIC50: 2.44E+5nMAssay Description:Inhibition of human DCPS using m7GMPF as substrate after 30 mins by nucleoside 5'-fluorophosphate probe based HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50452630(CHEMBL4203412)
Affinity DataKi:  3.82E+5nMAssay Description:Inhibition of eIF4E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed