Compile Data Set for Download or QSAR
Report error Found 64 Enz. Inhib. hit(s) with all data for entry = 50000478
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296301(US10112937, Example 404)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296301(US10112937, Example 404)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254305(US9464084, 202 | US10112937, Example 202 | US10150...)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296311(US10112937, Example 420)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254314(US9464084, 212 | US10112937, Example 212 | US10150...)
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254305(US9464084, 202 | US10112937, Example 202 | US10150...)
Affinity DataIC50: 4.10nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254320(US9464084, 220 | US10112937, Example 220 | US10150...)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254320(US9464084, 220 | US10112937, Example 220 | US10150...)
Affinity DataIC50: 5.90nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254314(US9464084, 212 | US10112937, Example 212 | US10150...)
Affinity DataIC50: 7.30nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254381(US9464084, 288 | US10112937, Example 288 | US10150...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254286(US9464084, 183 | US10112937, Example 183 | US10150...)
Affinity DataIC50: 9.40nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254381(US9464084, 288 | US10112937, Example 288 | US10150...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296311(US10112937, Example 420)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254326(US9464084, 228 | US10112937, Example 228 | US10150...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296305(BDBM50251203 | US10112937, Example 410)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296305(BDBM50251203 | US10112937, Example 410)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254286(US9464084, 183 | US10112937, Example 183 | US10150...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254310(US9464084, 208 | US10112937, Example 208 | US10150...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296320(US10112937, Example 429)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254310(US9464084, 208 | US10112937, Example 208 | US10150...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254326(US9464084, 228 | US10112937, Example 228 | US10150...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296303(US10112937, Example 406)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50251202(CHEMBL3936866)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296320(US10112937, Example 429)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254381(US9464084, 288 | US10112937, Example 288 | US10150...)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296311(US10112937, Example 420)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296303(US10112937, Example 406)
Affinity DataIC50: 404nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254314(US9464084, 212 | US10112937, Example 212 | US10150...)
Affinity DataIC50: 500nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide or diclofenac as substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254381(US9464084, 288 | US10112937, Example 288 | US10150...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide or diclofenac as substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296301(US10112937, Example 404)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide or diclofenac as substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296301(US10112937, Example 404)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296303(US10112937, Example 406)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50251200(CHEMBL4084212)
Affinity DataIC50: 2.89E+3nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254326(US9464084, 228 | US10112937, Example 228 | US10150...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG channel expressed in CHO cells at holding potential of -80 mV after 5 mins by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254320(US9464084, 220 | US10112937, Example 220 | US10150...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG channel expressed in CHO cells at holding potential of -80 mV after 5 mins by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254305(US9464084, 202 | US10112937, Example 202 | US10150...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296311(US10112937, Example 420)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide or diclofenac as substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50251200(CHEMBL4084212)
Affinity DataIC50: 4.03E+3nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254310(US9464084, 208 | US10112937, Example 208 | US10150...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254286(US9464084, 183 | US10112937, Example 183 | US10150...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254314(US9464084, 212 | US10112937, Example 212 | US10150...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide or diclofenac as substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50251202(CHEMBL3936866)
Affinity DataIC50: 6.20E+3nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254320(US9464084, 220 | US10112937, Example 220 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide or diclofenac as substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50251202(CHEMBL3936866)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254320(US9464084, 220 | US10112937, Example 220 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254320(US9464084, 220 | US10112937, Example 220 | US10150...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone, midozolam or nifedipine as substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
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