Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50001180
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50185127(30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-be...)
Affinity DataKd:  1.03E+5nMAssay Description:Binding affinity to recombinant HMGB1 A box region (1 to 89 residues) (unknown origin) expressed Escherichia coli after 5 mins by fluorescence-based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50185127(30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-be...)
Affinity DataKd:  8.70E+4nMAssay Description:Binding affinity to recombinant HMGB1 B box region (90 to 175 residues) (unknown origin) expressed Escherichia coli after 5 mins by fluorescence-base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM66082(SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...)
Affinity DataKd:  500nMAssay Description:Binding affinity to N-terminal 6His-tagged HMGB1 AI region (1 to 87 residues) (unknown origin) expressed in Escherichia coli JM109 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM26193(salicylic acid | 2-Hydroxybenzoate, I | CHEMBL424 ...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to recombinant HMGB1 box A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50271261(CHEMBL4129393)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to recombinant HMGB1 box A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50271261(CHEMBL4129393)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to recombinant HMGB1 box B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetToll-like receptor 4/MD-2(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50271262(CHEMBL4125967)
Affinity DataKd:  5.95E+3nMAssay Description:Binding affinity to recombinant human 10His-tagged TLR4 (24 to 631 residues)/recombinant human 10His-tagged MD2 (17 to 160 residues) after 5 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM66082(SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...)
Affinity DataKd:  24nMAssay Description:Binding affinity to N-terminal 6His-tagged HMGB1 Bj region (88 to 181 residues) (unknown origin) expressed in Escherichia coli JM109 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM26193(salicylic acid | 2-Hydroxybenzoate, I | CHEMBL424 ...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to recombinant HMGB1 box B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetLymphocyte antigen 96(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandPNGBDBM50271263(CHEMBL4125910)
Affinity DataKd:  650nMAssay Description:Binding affinity to human MD-2 (17 to 160 residues) assessed as reduction in MD-2 binding to human HMGB1 after 7 mins by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed