Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50002568
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460035(CHEMBL4227505)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM276743(US10071991, Compound (P) | US9611259, Compound (P)...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460036(CHEMBL4225509)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMast/stem cell growth factor receptor Kit(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460038(CHEMBL4224714)
Affinity DataIC50: 16nMAssay Description:Inhibition of KIT (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460039(CHEMBL4229168)
Affinity DataIC50: 26nMAssay Description:Inhibition of CSF1-stimulated CSF1R (unknown origin) phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460038(CHEMBL4224714)
Affinity DataIC50: 28nMAssay Description:Inhibition of CSF1R (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460039(CHEMBL4229168)
Affinity DataIC50: 33nMAssay Description:Inhibition of IL34-stimulated CSF1R (unknown origin) phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460039(CHEMBL4229168)
Affinity DataIC50: 38nMAssay Description:Inhibition of CSF1R (unknown origin) assessed as inhibition of CSF1-stimulated cell growth by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460039(CHEMBL4229168)
Affinity DataIC50: 40nMAssay Description:Inhibition of CSF1R (unknown origin) assessed as inhibition of IL34-stimulated cell growth by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460037(CHEMBL4228766)
Affinity DataIC50: 46nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM32362(cid_11617559 | GW-2580 | 5-[[3-methoxy-4-[(4-metho...)
Affinity DataIC50: 60nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460037(CHEMBL4228766)
Affinity DataIC50: 62nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460040(CHEMBL4226338)
Affinity DataIC50: 62nMAssay Description:Inhibition of CSF1R (unknown origin) using biotinylated peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460037(CHEMBL4228766)
Affinity DataIC50: 69nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460039(CHEMBL4229168)
Affinity DataIC50: 88nMAssay Description:Inhibition of CSF1R in human monocytes assessed as inhibition of IL34-stimulated MCP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460039(CHEMBL4229168)
Affinity DataIC50: 93nMAssay Description:Inhibition of CSF1R in human monocytes assessed as inhibition of CSF1-stimulated MCP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM32362(cid_11617559 | GW-2580 | 5-[[3-methoxy-4-[(4-metho...)
Affinity DataIC50: 140nMAssay Description:Inhibition of CSF1R in human monocytes assessed as inhibition of IL34-stimulated MCP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM32362(cid_11617559 | GW-2580 | 5-[[3-methoxy-4-[(4-metho...)
Affinity DataIC50: 148nMAssay Description:Inhibition of CSF1R in human monocytes assessed as inhibition of CSF1-stimulated MCP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460037(CHEMBL4228766)
Affinity DataIC50: 230nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50460037(CHEMBL4228766)
Affinity DataIC50: 277nMAssay Description:Inhibition of CSF1R signaling in human PBMC assessed as reduction in M-CSF-induced differentiation after 7 days by immunostaining analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50277584(N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CSF-stimulated CSF1R phosphorylation in human MV4-11 cells by immunoblotting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed