Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50001801
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50078850(CHEBI:4778 | Embelin)
Affinity DataIC50: 200nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50366305(CHEMBL445599 | CHEBI:70328)
Affinity DataIC50: 300nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 300nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50369678(CHEMBL3770253)
Affinity DataIC50: 400nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50109833(Arzanol)
Affinity DataIC50: 400nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50369679(CHEMBL2006643)
Affinity DataIC50: 430nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50193079(CHEMBL1237210 | CHEBI:5834)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mPGES1 (unknown origin) assessed as reduction in conversion of PGH to PGE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50056919(CHEMBL173395 | 3-hydroxy-4-(methoxycarbonyl)-2,5-d...)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin-3-o-gallate | (-)-Epigallocat...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50369681(CHEMBL4163039)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50006805(CHEMBL29097 | 3-(3-(tert-butylthio)-1-(4-chloroben...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50006805(CHEMBL29097 | 3-(3-(tert-butylthio)-1-(4-chloroben...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50369680(CHEMBL4170957)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50241262(3-O-acetyl-11-keto-beta-boswellic acid | 3alpha-ac...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50213683(carnosol | CHEMBL218693)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50241260(boswellic acid | (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50006805(CHEMBL29097 | 3-(3-(tert-butylthio)-1-(4-chloroben...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 5 mins by HPLC a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Abdul Wali Khan University Mardan

Curated by ChEMBL
LigandPNGBDBM50241261(11-keto-beta-boswellicacid | (3R,4R,4aR,6aR,6bS,8a...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed