Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with all data for entry = 50002379
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50147818((2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-...)
Affinity DataKi:  0.00140nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50147818((2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-...)
Affinity DataKi:  0.00140nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50147824(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.00140nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50147824(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  0.00150nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457929(CHEMBL104951)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457933(CHEMBL327265)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457929(CHEMBL104951)
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457933(CHEMBL327265)
Affinity DataKi: <0.0100nMAssay Description:Binding affinity to thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM12751(CHEMBL152854 | 1-(3-carbamimidoylphenyl)-3-methyl-...)
Affinity DataKi:  0.0130nMAssay Description:Inhibition of human factor 10a using S-2765 as substrate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50123490(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-[3-(2,2-...)
Affinity DataKi:  0.0420nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50067796(L-374087 | N-(6-Amino-2-methyl-pyridin-3-ylmethyl)...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124086(2-[6-Methyl-2-oxo-3-(2-pyridin-2-yl-ethylamino)-2H...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124093(N-(1H-Indol-5-ylmethyl)-2-[6-methyl-2-oxo-3-(2-pyr...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50126302(2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINY...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50123481(2-[6-Cyano-3-(2,2-difluoro-2-pyridin-2-yl-ethylami...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50126298(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50126316(2-{6-Chloro-3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124092(2-(6-Methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50123491(2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50123494(2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylam...)
Affinity DataKi:  5.20nMAssay Description:Inhibition of thrombin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50112083(3-({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-met...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human thrombin using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50112086(CHEMBL48361 | 3-({2-[(4-Carbamimidoyl-phenylamino)...)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of human thrombin using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50112085([{2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-methy...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human thrombin using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM12751(CHEMBL152854 | 1-(3-carbamimidoylphenyl)-3-methyl-...)
Affinity DataKi:  16nMAssay Description:Inhibition of human trypsin using S-2222 as substrate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14593(CHEMBL77076 | 3-amino-5-[1-({[(4-carbamimidoylphen...)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant soluble tissue factor (unknown origin)/recombinant human factor 7a using N-methylsulfonyl-D-phe-gly arg-p-nitroaniline as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50124097(N-(1H-Indol-5-ylmethyl)-2-(6-methyl-2-oxo-3-phenet...)
Affinity DataKi:  18nMAssay Description:Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant soluble tissue factor (unknown origin)/recombinant human factor 7a using N-methylsulfonyl-D-phe-gly arg-p-nitroaniline as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50112073([{2-[2-(4-Carbamimidoyl-phenyl)-ethyl]-1-methyl-1H...)
Affinity DataIC50: 32nMAssay Description:Inhibition of human thrombin using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14497(N-{4-[Amino(imino)methyl]benzyl}-2-[6-(3,5-diamino...)
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant human soluble tissue factor (1 to 219 residues) expressed in Escherichia coli/recombinant human factor 7a using N-methylsul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50112081([[2-(4-Carbamimidoyl-phenoxymethyl)-1-methyl-1H-be...)
Affinity DataIC50: 58nMAssay Description:Inhibition of human thrombin using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14498(CHEMBL75084 | N-[(4-carbamimidoylphenyl)methyl]-2-...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human thrombin using H-D-phenylalanyl-L-pipecolyl-L-arginine-p-nitroaniline dihydrochloride as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457934(CHEMBL23430)
Affinity DataIC50: 169nMAssay Description:Inhibition of human trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457932(CHEMBL4202662)
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant soluble tissue factor (unknown origin)/recombinant human factor 7a using N-methylsulfonyl-D-phe-gly arg-p-nitroaniline as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM12751(CHEMBL152854 | 1-(3-carbamimidoylphenyl)-3-methyl-...)
Affinity DataKi:  300nMAssay Description:Inhibition of human thrombin using S-2366 as substrate after 30 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 340nMAssay Description:Inhibition of recombinant human soluble tissue factor (1 to 219 residues) expressed in Escherichia coli/recombinant human factor 7a using N-methylsul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14498(CHEMBL75084 | N-[(4-carbamimidoylphenyl)methyl]-2-...)
Affinity DataIC50: 630nMAssay Description:Inhibition of recombinant soluble tissue factor (unknown origin)/recombinant human factor 7a using N-methylsulfonyl-D-phe-gly arg-p-nitroaniline as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457934(CHEMBL23430)
Affinity DataIC50: 690nMAssay Description:Inhibition of human thrombin using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14510(2-[3-(benzylamino)-5-chloro-2-oxo-6-phenyl-1,2-dih...)
Affinity DataIC50: 770nMAssay Description:Inhibition of recombinant soluble tissue factor (unknown origin)/recombinant human factor 7a using N-methylsulfonyl-D-phe-gly arg-p-nitroaniline as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50123490(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-[3-(2,2-...)
Affinity DataKi:  800nMAssay Description:Inhibition of trypsin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457931(CHEMBL4213790)
Affinity DataIC50: 820nMAssay Description:Inhibition of tissue factor/factor 7a (unknown origin)-induced factor 10 activation using S-2765 as substrate preincubated for 5 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14597(2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-bipheny...)
Affinity DataIC50: 950nMAssay Description:Inhibition of human thrombin using H-D-phenylalanyl-L-pipecolyl-L-arginine-p-nitroaniline dihydrochloride as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457938(CHEMBL4209404)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of tissue factor/factor 7a (unknown origin)-induced factor 10 activation using S-2765 as substrate preincubated for 5 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457930(CHEMBL4208864)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of tissue factor/factor 7a (unknown origin)-induced factor 10 activation using S-2765 as substrate preincubated for 5 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50067797(N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methy...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457935(CHEMBL4203384)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of tissue factor/factor 7a (unknown origin)-induced factor 10 activation using S-2765 as substrate preincubated for 5 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457940(CHEMBL4215577)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant human soluble tissue factor (1 to 219 residues) expressed in Escherichia coli/recombinant human factor 7a using N-methylsul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50457936(CHEMBL4208256)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of tissue factor/factor 7a (unknown origin)-induced factor 10 activation using S-2765 as substrate preincubated for 5 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTrypsin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50067796(L-374087 | N-(6-Amino-2-methyl-pyridin-3-ylmethyl)...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14510(2-[3-(benzylamino)-5-chloro-2-oxo-6-phenyl-1,2-dih...)
Affinity DataIC50: 7.63E+3nMAssay Description:Inhibition of human thrombin using H-D-phenylalanyl-L-pipecolyl-L-arginine-p-nitroaniline dihydrochloride as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
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