Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50001693
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using ULight-poly GT as substrate preincubated for 120 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human N-terminal His-tagged EGFR (1 to 645 residues) expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292577(CHEMBL4161938)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human N-terminal His-tagged EGFR (1 to 645 residues) expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292577(CHEMBL4161938)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) preincubated for 10 mins followed by TK substrate-botion addition measured after 1 hr by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292568(CHEMBL4173696)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human N-terminal His-tagged EGFR (1 to 645 residues) expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human N-terminal His-tagged EGFR (1 to 645 residues) expressed in HEK293 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 128nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) preincubated for 10 mins followed by TK substrate-botion addition measured after 1 hr by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292568(CHEMBL4173696)
Affinity DataIC50: 236nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using ULight-poly GT as substrate preincubated for 120 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292577(CHEMBL4161938)
Affinity DataIC50: 323nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using ULight-poly GT as substrate preincubated for 120 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292568(CHEMBL4173696)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) preincubated for 10 mins followed by TK substrate-botion addition measured after 1 hr by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292568(CHEMBL4173696)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) using ULight-poly GT as substrate preincubated for 30 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM50292577(CHEMBL4161938)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) using ULight-poly GT as substrate preincubated for 30 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shaanxi Normal University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of EGFR L858R/T790M double mutant (unknown origin) using ULight-poly GT as substrate preincubated for 30 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)