Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50002409
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50458259(CHEMBL4215992)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells assessed as suppression of Wnt signaling after 48 hrs by Super-top flash...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50133870(CHEMBL3188386 | CHEBI:78030 | US10251893, Compound...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells assessed as suppression of Wnt signaling after 48 hrs by Super-top flash...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50458258(CHEMBL4215124)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells assessed as suppression of Wnt signaling after 48 hrs by Super-top flash...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50197186(CHEMBL3923788)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells assessed as suppression of Wnt signaling after 48 hrs by Super-top flash...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 6nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse NIH3T3 cells expressing GRE-Luc reporter gene assessed as inhibition of SAG-induced GR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50197203(CHEMBL3910011)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells assessed as suppression of Wnt signaling after 48 hrs by Super-top flash...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50197277(CHEMBL3972086)
Affinity DataIC50: 71nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse NIH3T3 cells expressing GRE-Luc reporter gene assessed as inhibition of SAG-induced GR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50458259(CHEMBL4215992)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse NIH3T3 cells expressing GRE-Luc reporter gene assessed as inhibition of SAG-induced GR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50458258(CHEMBL4215124)
Affinity DataIC50: 3.66E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse NIH3T3 cells expressing GRE-Luc reporter gene assessed as inhibition of SAG-induced GR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50197277(CHEMBL3972086)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Bodipy-cyclopamine binding to human Smo expressed in human U2OS cells after 2 hrs by high content fluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed