Compile Data Set for Download or QSAR
Report error Found 87 Enz. Inhib. hit(s) with all data for entry = 50000630
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataIC50: 6nMAssay Description:Inhibition of human plasma kallikrein spiked in pig vitreous using HMWK as substrate assessed as suppression of bradykinin release preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256261(CHEMBL4059991)
Affinity DataIC50: 27nMAssay Description:Inhibition of human plasma kallikrein spiked in pig vitreous using HMWK as substrate assessed as suppression of bradykinin release preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataIC50: 120nMAssay Description:Inhibition of plasma kallikrein in human plasma using HMWK as substrate assessed as suppression of kaolin-activated protein induced bradykinin releas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256261(CHEMBL4059991)
Affinity DataIC50: 790nMAssay Description:Inhibition of plasma kallikrein in human plasma using HMWK as substrate assessed as suppression of kaolin-activated protein induced bradykinin releas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256265(CHEMBL4089486)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256283(CHEMBL4079711)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256264(CHEMBL4099333)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256277(CHEMBL4093698)
Affinity DataKi:  0.150nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256286(CHEMBL4076199)
Affinity DataKi:  0.210nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataKi:  0.360nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256276(CHEMBL4079260)
Affinity DataKi:  0.390nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Rat)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256284(CHEMBL4075544)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256288(CHEMBL4085408)
Affinity DataKi:  0.440nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Rat)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256283(CHEMBL4079711)
Affinity DataKi:  0.900nMAssay Description:Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256263(CHEMBL4088185)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Rat)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256277(CHEMBL4093698)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256287(CHEMBL4105318)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256284(CHEMBL4075544)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256261(CHEMBL4059991)
Affinity DataKi:  3nMAssay Description:Inhibition of human plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Rat)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256261(CHEMBL4059991)
Affinity DataKi:  3.40nMAssay Description:Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetKallikrein(Pig)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256277(CHEMBL4093698)
Affinity DataKi:  3.60nMAssay Description:Inhibition of pig plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Rat)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  5.5nMAssay Description:Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Rat)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256276(CHEMBL4079260)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetKallikrein(Pig)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256276(CHEMBL4079260)
Affinity DataKi:  22nMAssay Description:Inhibition of pig plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Rat)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataKi:  30nMAssay Description:Inhibition of recombinant Sprague-Dawley rat plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Mouse)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  45nMAssay Description:Inhibition of recombinant mouse C-terminal 6His-tagged plasma kallikrein (20 to 638 residues) using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Mouse)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256261(CHEMBL4059991)
Affinity DataKi:  54nMAssay Description:Inhibition of recombinant mouse C-terminal 6His-tagged plasma kallikrein (20 to 638 residues) using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetPlasma kallikrein(Mouse)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataKi:  120nMAssay Description:Inhibition of recombinant mouse C-terminal 6His-tagged plasma kallikrein (20 to 638 residues) using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetKallikrein(Pig)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  300nMAssay Description:Inhibition of pig plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetKallikrein(Pig)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256261(CHEMBL4059991)
Affinity DataKi:  410nMAssay Description:Inhibition of pig plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  500nMAssay Description:Inhibition of human factor 11a using fluorogenic peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetKallikrein(Pig)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataKi:  510nMAssay Description:Inhibition of pig plasma kallikrein using fluorogenic H-Pro-Phe-Arg-AMC peptide as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetKallikrein-5(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  800nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged KLK5 (67 to 293 residues) expressed in mouse NS0 cells using fluorogenic Boc-VPR-AMC peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetKallikrein-13(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  820nMAssay Description:Inhibition of recombinant human C-terminal polyHis-tagged KLK13 (1 to 262 residues) expressed in HEK293 cells using fluorogenic Boc-VPR-AMC peptide a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256285(CHEMBL4086746)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of factor 11a (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetKallikrein-14(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged KLK14 (19 to 248 residues) expressed in mouse NS0 cells using fluorogenic Boc-VPR-AMC peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetKallikrein-2(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged KLK2 (1 to 261 residues) expressed in mouse NS0 cells using fluorogenic PFR-AMC peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetKallikrein-2(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged KLK2 (1 to 261 residues) expressed in mouse NS0 cells using fluorogenic PFR-AMC peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of recombinant human N-terminal 6His-tagged matriptase catalytic domain (596 to 855 residues) expressed in Escherichia coli using fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged factor Xa (24 to 488 residues) expressed in baculovirus derived insect sf21 cells using fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetSuppressor of tumorigenicity 14 protein(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256261(CHEMBL4059991)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibition of recombinant human N-terminal 6His-tagged matriptase catalytic domain (596 to 855 residues) expressed in Escherichia coli using fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged factor Xa (24 to 488 residues) expressed in baculovirus derived insect sf21 cells using fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256261(CHEMBL4059991)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human factor 11a using fluorogenic peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human factor 11a using fluorogenic peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256261(CHEMBL4059991)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 10His-tagged factor Xa (24 to 488 residues) expressed in baculovirus derived insect sf21 cells using fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256261(CHEMBL4059991)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human factor 7a using fluorogenic peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetCathepsin G(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256262(CHEMBL4070056)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human Cathepsin-GMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetProthrombin(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human alpha thrombin using fluorogenic peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetComplement C1s subcomponent(Human)
Bicycle Therapeutics

Curated by ChEMBL
LigandPNGBDBM50256260(CHEMBL4094403)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged complement component C1s (1 to 688 residues) expressed in mouse NS0 cells using fluorogenic Z-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
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