Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50002423
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM33960(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)
Affinity DataIC50: 400nMAssay Description:Inhibition of HIV1 reverse transcriptase polymerase p51/p66 after 10 to 20 mins in presence of [3H]-TTP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50: 500nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H using RNA-DNA hybrid duplex after 30 mins by FRET-based microplate fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM33959(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)
Affinity DataIC50: 500nMAssay Description:Inhibition of HIV1 reverse transcriptase polymerase p51/p66 after 10 to 20 mins in presence of [3H]-TTP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50458413(CHEMBL3142917)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of HIV1 3B reverse transcriptase using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf thymus DNA after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50148764([1-[2',5'-Bis-O-(tert-butyldimethylsilyl)-beta-D-r...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of HIV1 3B reverse transcriptase using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf thymus DNA after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50148763([1-[2',5'-Bis-O-(tert-butyldimethylsilyl)-beta-D-r...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of HIV1 3B reverse transcriptase using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf thymus DNA after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50148760([1-[2',5'-Bis-O-(tert-butyldimethylsilyl)-beta-D-r...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of HIV1 3B reverse transcriptase using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf thymus DNA after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM33959(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H using RNA-DNA hybrid duplex after 30 mins by FRET-based microplate fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM33960(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H using RNA-DNA hybrid duplex after 30 mins by FRET-based microplate fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGag-Pol polyprotein(HIV-1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50458414(CHEMBL4211455)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of HIV1 reverse transcriptase polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50458414(CHEMBL4211455)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of HIV1 reverse transcriptase polymerase p51/p66 after 10 to 20 mins in presence of [3H]-TTP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein(HIV-1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of HIV1 reverse transcriptase polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50148764([1-[2',5'-Bis-O-(tert-butyldimethylsilyl)-beta-D-r...)
Affinity DataIC50: 2.93E+5nMAssay Description:Inhibition of TSAO resistant HIV1 3B reverse transcriptase E138K mutant using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50458413(CHEMBL3142917)
Affinity DataIC50: 2.93E+5nMAssay Description:Inhibition of TSAO resistant HIV1 3B reverse transcriptase E138K mutant using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50148760([1-[2',5'-Bis-O-(tert-butyldimethylsilyl)-beta-D-r...)
Affinity DataIC50: 2.93E+5nMAssay Description:Inhibition of TSAO resistant HIV1 3B reverse transcriptase E138K mutant using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50148763([1-[2',5'-Bis-O-(tert-butyldimethylsilyl)-beta-D-r...)
Affinity DataIC50: 2.93E+5nMAssay Description:Inhibition of TSAO resistant HIV1 3B reverse transcriptase E138K mutant using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed