Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50002746
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50462413(CHEMBL4248257)
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50012860(CHEMBL61422 | 1-Oxo-1,2-dihydro-6-oxa-10b-aza-acea...)
Affinity DataIC50: 20nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL-1 cells preincubated for 10 mins followed by [14C]arachidonic acid addition and measured after 5 mins by radi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetEndothelial lipase(Mouse)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50443625(CHEMBL3092448 | US9216998, 25)
Affinity DataIC50: 31nMAssay Description:Inhibition of endothelial lipase in mouse cells after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetEndothelial lipase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50443625(CHEMBL3092448 | US9216998, 25)
Affinity DataIC50: 39nMAssay Description:Inhibition of endothelial lipase in human cells after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMicrotubule-associated protein 2(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50462411(CHEMBL4249788)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant MetAP2 expressed in Sf9 insect cells using MAS as substrate after 30 mins by fluorometeric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Rat)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50012860(CHEMBL61422 | 1-Oxo-1,2-dihydro-6-oxa-10b-aza-acea...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of cyclooxygenase-1 in rat RBL-1 cells preincubated for 10 mins followed by [14C]arachidonic acid addition and measured after 5 mins by ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Rat)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50462412(CHEMBL4243676)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Nav1.7 in rat dorsal root ganglions at -60 mV holding potential by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50462410(CHEMBL4243096)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase expressed in Escherichia coli BL21 (DE3) using biotinylated oligo-dT12 primer as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50462414(CHEMBL2003451)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of bovine AChE using ACH iodide as substrate preincubated for 60 mins followed by substrate addition and measured after 1 hrs by spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed