Compile Data Set for Download or QSAR
Report error Found 82 Enz. Inhib. hit(s) with all data for entry = 50001721
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321325(CHEMBL4173485)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321332(CHEMBL4165554)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321330(CHEMBL4166624)
Affinity DataEC50:  77nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321318(CHEMBL4166415)
Affinity DataEC50:  85nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321325(CHEMBL4173485)
Affinity DataEC50:  99nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321318(CHEMBL4166415)
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321436(CHEMBL4162962)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321942(CHEMBL4170773)
Affinity DataEC50:  210nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321319(CHEMBL4168975)
Affinity DataEC50:  230nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321386(CHEMBL4170344)
Affinity DataEC50:  250nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50336021(CHEMBL4174655)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321319(CHEMBL4168975)
Affinity DataIC50: 290nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321329(CHEMBL4177244)
Affinity DataEC50:  340nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321330(CHEMBL4166624)
Affinity DataIC50: 340nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321331(CHEMBL4166941)
Affinity DataEC50:  360nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321386(CHEMBL4170344)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321942(CHEMBL4170773)
Affinity DataIC50: 580nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321331(CHEMBL4166941)
Affinity DataIC50: 640nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321436(CHEMBL4162962)
Affinity DataEC50:  670nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50335565(CHEMBL4176841)
Affinity DataEC50:  810nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321332(CHEMBL4165554)
Affinity DataEC50:  810nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321321(CHEMBL4165043)
Affinity DataEC50:  820nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321335(CHEMBL4160126)
Affinity DataIC50: 830nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321335(CHEMBL4160126)
Affinity DataEC50:  950nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321323(CHEMBL4177147)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50335521(CHEMBL4159044)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50335520(CHEMBL4162432)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50335565(CHEMBL4176841)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321329(CHEMBL4177244)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321321(CHEMBL4165043)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321323(CHEMBL4177147)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321386(CHEMBL4170344)
Affinity DataIC50: 2.94E+3nMAssay Description:Competitive inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50335520(CHEMBL4162432)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321335(CHEMBL4160126)
Affinity DataIC50: 4.21E+3nMAssay Description:Competitive inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321328(CHEMBL4163495)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50335521(CHEMBL4159044)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50440736(CHEMBL2431088)
Affinity DataEC50:  9.70E+3nMAssay Description:Inhibition of TDO2 in human SW48 cells assessed as decrease in conversion of tryptophan to N-formylkynurenine after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321318(CHEMBL4166415)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321318(CHEMBL4166415)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321330(CHEMBL4166624)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321319(CHEMBL4168975)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321330(CHEMBL4166624)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321325(CHEMBL4173485)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321330(CHEMBL4166624)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321325(CHEMBL4173485)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321319(CHEMBL4168975)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321325(CHEMBL4173485)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321325(CHEMBL4173485)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321318(CHEMBL4166415)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50321319(CHEMBL4168975)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
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