Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50002367
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50: 260nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50: 370nMAssay Description:Inhibition of PKC in TLR null HEK-blue cells assessed as inhibition of PMA-induced NF-kappaB activation-mediated SEAP production after 24 hrs by Quan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457672(CHEMBL4206455)
Affinity DataIC50: 440nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457671(CHEMBL4218718)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50: 590nMAssay Description:Inhibition of PKC in HEK-blue cells expressing human TLR7 assessed as inhibition of PMA-induced NF-kappaB activation-mediated SEAP production after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInterleukin-1 receptor type 1(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50: 720nMAssay Description:Inhibition of IL1R in TLR null HEK-blue cells assessed as decrease in IL-1beta-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTumor necrosis factor receptor superfamily member 1A(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50: 770nMAssay Description:Inhibition of TNFR in TLR null HEK-blue cells assessed as decrease in TNFalpha-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457651(CHEMBL4207325)
Affinity DataIC50: 900nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457650(CHEMBL4205530)
Affinity DataIC50: 990nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457678(CHEMBL4202439)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457674(CHEMBL4206802)
Affinity DataIC50: 1.02E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457668(CHEMBL4217241)
Affinity DataIC50: 1.83E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457652(CHEMBL4214295)
Affinity DataIC50: 1.90E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457667(CHEMBL4205580)
Affinity DataIC50: 2.10E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457677(CHEMBL4209891)
Affinity DataIC50: 2.40E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457673(CHEMBL4218186)
Affinity DataIC50: 2.60E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457669(CHEMBL4205022)
Affinity DataIC50: 3.09E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457670(CHEMBL4209402)
Affinity DataIC50: 3.90E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457666(CHEMBL4217286)
Affinity DataIC50: 4.40E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457684(CHEMBL4213411)
Affinity DataIC50: 5.80E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457661(CHEMBL4206397)
Affinity DataIC50: 7.90E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457681(CHEMBL4218120)
Affinity DataIC50: 1.34E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457665(CHEMBL4208477)
Affinity DataIC50: 1.40E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457658(CHEMBL4208105)
Affinity DataIC50: 1.42E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457680(CHEMBL4209122)
Affinity DataIC50: 1.50E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457657(CHEMBL4215965)
Affinity DataIC50: 1.60E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457659(CHEMBL4207939)
Affinity DataIC50: 1.70E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457654(CHEMBL4214303)
Affinity DataIC50: 1.70E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457675(CHEMBL4218660)
Affinity DataIC50: 1.73E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457683(CHEMBL4203056)
Affinity DataIC50: 2.20E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457676(CHEMBL4209015)
Affinity DataIC50: 2.32E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457660(CHEMBL4202634)
Affinity DataIC50: 2.47E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457656(CHEMBL4211005)
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457653(CHEMBL4210840)
Affinity DataIC50: 2.70E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457662(CHEMBL4213731)
Affinity DataIC50: 2.78E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457664(CHEMBL4204673)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457679(CHEMBL4206630)
Affinity DataIC50: 3.80E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457663(CHEMBL1467989)
Affinity DataIC50: 4.48E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Colorado

Curated by ChEMBL
LigandPNGBDBM50457682(CHEMBL4207057)
Affinity DataIC50: 6.00E+4nMAssay Description:Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed