Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50001329
TargetAmine oxidase [flavin-containing] B(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276359(CHEMBL4129303)
Affinity DataIC50: 0.134nMAssay Description:Inhibition of human MAO-B using p-tyramine as substrate after 15 mins by amplex red reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276368(CHEMBL4128371)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM15579(US8633208, Deprenyl | CHEMBL972 | L-Deprenyl | SLG...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human MAO-B using p-tyramine as substrate after 15 mins by amplex red reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 86nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Bovine)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM193852((E)-3-(2-(2-(1-(4-bromophenyl)ethylidene)hydraziny...)
Affinity DataIC50: 110nMAssay Description:Inhibition of calf lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by UV sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human COX1 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by TLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276360(CHEMBL4126559)
Affinity DataIC50: 310nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276369(CHEMBL4127948)
Affinity DataIC50: 310nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Bovine)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM193866(3-(4-((2-Chlorophenylamino)methyl)-5-thioxo-4,5-di...)
Affinity DataIC50: 310nMAssay Description:Inhibition of calf lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by UV sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276310(CHEMBL4127794)
Affinity DataIC50: 310nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276366(CHEMBL4129984)
Affinity DataIC50: 310nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Bovine)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM193869(3-(4-(Morpholinomethyl)-5-thioxo-4,5-dihydro-1,3,4...)
Affinity DataIC50: 340nMAssay Description:Inhibition of calf lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by UV sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 360nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276367(CHEMBL4129191)
Affinity DataIC50: 390nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Bovine)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM193860((E)-3-(2-(2-((2-amino-4-chlorophenyl)(phenyl)methy...)
Affinity DataIC50: 459nMAssay Description:Inhibition of bovine kidney ALR1 using D-glucoronic acid as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by UV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetIntestinal-type alkaline phosphatase(Bovine)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276361(CHEMBL4129493)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of calf intestinal alkaline phosphatase using pNPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 2.41E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 2.63E+3nMAssay Description:Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B1(Bovine)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM193864(3-(4-((Butylamino)methyl)-5-thioxo-4,5-dihydro-1,3...)
Affinity DataIC50: 3.36E+3nMAssay Description:Inhibition of bovine kidney ALR1 using D-glucoronic acid as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by UV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50: 4.15E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM152478(1-(4-(8-Methoxy-2-oxo-2H-chromen-3-yl)thiazol-2-yl...)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM152467(1-(4-Fluorophenyl)-3-(4-(6-nitro-2-oxo-2H-chromen-...)
Affinity DataIC50: 4.93E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276371(CHEMBL4128061)
Affinity DataIC50: 5.85E+3nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured at 1 min ti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetLipoxygenase(Soybean)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276365(CHEMBL4127281)
Affinity DataIC50: 6.25E+3nMAssay Description:Inhibition of soybean lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human erythrocyte AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured at 1 min ti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50031467(Kojic Acid | CHEMBL287556 | 5-HYDROXY-2-(HYDROXYME...)
Affinity DataIC50: 1.68E+4nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetLipoxygenase(Soybean)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276370(CHEMBL4126039)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of soybean lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetLipoxygenase(Soybean)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM32020(LOX inhibitor, N/A | 4-[4-(3,4-dihydroxyphenyl)-2,...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of soybean lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetCholinesterase(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276371(CHEMBL4128061)
Affinity DataIC50: 3.25E+4nMAssay Description:Inhibition of human plasmatic BuChE using butylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured at 1 min time...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276360(CHEMBL4126559)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human COX1 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by TLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276310(CHEMBL4127794)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human COX1 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by TLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276367(CHEMBL4129191)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human COX1 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by TLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276366(CHEMBL4129984)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human COX1 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by TLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50276369(CHEMBL4127948)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human COX1 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by TLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Abbottabad University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  25nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 assessed as reduction in CO2 hydration preincubated for 10 mins by stopped flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2020
Entry Details Article
PubMed