Compile Data Set for Download or QSAR
Report error Found 99 Enz. Inhib. hit(s) with all data for entry = 50002506
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459434(CHEMBL4214703)
Affinity DataKd:  9nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459440(CHEMBL4203017)
Affinity DataKd:  12nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459433(CHEMBL4208983)
Affinity DataKd:  12nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459441(CHEMBL4215883)
Affinity DataKd:  16nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459477(CHEMBL4210312)
Affinity DataKd:  36nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459449(CHEMBL4213025)
Affinity DataKd:  44nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459448(CHEMBL4217599)
Affinity DataKd: <100nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459432(CHEMBL4212206)
Affinity DataKd:  100nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459435(CHEMBL4217185)
Affinity DataKd:  110nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459427(CHEMBL4214176)
Affinity DataKd:  120nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459470(CHEMBL4209907)
Affinity DataKd:  130nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459430(CHEMBL4214821)
Affinity DataKd:  140nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459473(CHEMBL4204971)
Affinity DataKd:  140nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459439(CHEMBL4215257)
Affinity DataKd:  140nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459468(CHEMBL4205351)
Affinity DataKd:  150nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459476(CHEMBL4205896)
Affinity DataKd:  180nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459422(CHEMBL4212702)
Affinity DataKd:  180nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459469(CHEMBL4202637)
Affinity DataKd:  200nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459428(CHEMBL4210108)
Affinity DataKd:  210nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459478(CHEMBL4206374)
Affinity DataKd:  210nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459431(CHEMBL4216651)
Affinity DataKd:  240nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459480(CHEMBL4203578)
Affinity DataKd:  240nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459451(CHEMBL4210420)
Affinity DataKd:  240nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459450(CHEMBL4205543)
Affinity DataKd:  250nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459465(CHEMBL4213612)
Affinity DataKd:  270nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459429(CHEMBL4214306)
Affinity DataKd:  300nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459471(CHEMBL4217774)
Affinity DataKd:  310nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459442(CHEMBL4209338)
Affinity DataKd:  330nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459475(CHEMBL4207854)
Affinity DataKd:  350nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459472(CHEMBL4206057)
Affinity DataKd:  380nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459474(CHEMBL4212756)
Affinity DataKd:  390nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459466(CHEMBL4209734)
Affinity DataKd:  390nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459467(CHEMBL4204856)
Affinity DataKd:  440nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459447(CHEMBL4204468)
Affinity DataKd:  450nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459438(CHEMBL4218552)
Affinity DataKd:  460nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459444(CHEMBL4217068)
Affinity DataKd:  670nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459464(CHEMBL4217465)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459419(CHEMBL4210407)
Affinity DataKd:  1.05E+3nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli by fluorescent probe ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459426(CHEMBL4212509)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459455(CHEMBL4203601)
Affinity DataEC50:  1.90E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459437(CHEMBL4210860)
Affinity DataEC50:  2.20E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459436(CHEMBL4208653)
Affinity DataEC50:  2.40E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459461(CHEMBL4204326)
Affinity DataEC50:  3.00E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459439(CHEMBL4215257)
Affinity DataEC50:  3.20E+3nMAssay Description:Activation of SOS1 in human HeLa cells expressing wild type KRAS assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 mins by I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459460(CHEMBL4215997)
Affinity DataEC50:  3.70E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459459(CHEMBL4209928)
Affinity DataEC50:  4.10E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459462(CHEMBL4208139)
Affinity DataEC50:  4.40E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459420(CHEMBL4203773)
Affinity DataEC50:  5.40E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459445(CHEMBL4215811)
Affinity DataEC50:  5.60E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50459449(CHEMBL4213025)
Affinity DataEC50:  5.90E+3nMAssay Description:Activation of SOS1 in human HeLa cells expressing wild type KRAS assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 mins by I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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