Compile Data Set for Download or QSAR
Report error Found 109 Enz. Inhib. hit(s) with all data for entry = 50001924
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM373015(US9896418, Compound 185 | US10597366, Compound 185)
Affinity DataEC50: <5nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372964(US9896418, Compound 8 | US10597366, Compound 8)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282632(US9884843, Compound 25 | 5-(3-Chloro-5-fluoropheno...)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282598(US9884843, Compound 14 | 5-(3-Chloro-5-fluoropheno...)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372960(US9896418, Compound 1 | US10597366, Compound 1)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372979(US9896418, Compound 17 | US10597366, Compound 17)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282572((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450475(CHEMBL4168682)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM373015(US9896418, Compound 185 | US10597366, Compound 185)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372991(US9896418, Compound 63 | US10597366, Compound 63)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282581(US9884843, Compound 9 | 4-Bromo-5-(3-chloro-5-fluo...)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372976(US9896418, Compound 15 | US10597366, Compound 15)
Affinity DataIC50: 5nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372976(US9896418, Compound 15 | US10597366, Compound 15)
Affinity DataEC50:  6nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372991(US9896418, Compound 63 | US10597366, Compound 63)
Affinity DataEC50:  9nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282572((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Affinity DataEC50:  10nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372972(US9896418, Compound 11 | US10597366, Compound 11)
Affinity DataIC50: 10nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282656(US9884843, Compound 22 | 4-(Difluoromethyl)-5-(3,5...)
Affinity DataIC50: 11nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM373008(US9896418, Compound 163 | US10597366, Compound 163)
Affinity DataIC50: 12nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282656(US9884843, Compound 22 | 4-(Difluoromethyl)-5-(3,5...)
Affinity DataEC50:  13nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282685(US9884843, Compound 40 | 3-((4-(Difluoromethyl)-2,...)
Affinity DataIC50: 14nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372976(US9896418, Compound 15 | US10597366, Compound 15)
Affinity DataEC50:  14nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells assessed as reduction in VEGFA concentration after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372972(US9896418, Compound 11 | US10597366, Compound 11)
Affinity DataEC50:  15nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282572((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...)
Affinity DataEC50:  16nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells assessed as reduction in VEGFA concentration after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450483(CHEMBL4176537)
Affinity DataIC50: 16nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282632(US9884843, Compound 25 | 5-(3-Chloro-5-fluoropheno...)
Affinity DataEC50:  17nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372964(US9896418, Compound 8 | US10597366, Compound 8)
Affinity DataEC50:  20nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282597(US9884843, Compound 13)
Affinity DataIC50: 20nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282584(US9884843, Compound 11 | 4-Chloro-5-(3-chloro-5-fl...)
Affinity DataIC50: 20nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372991(US9896418, Compound 63 | US10597366, Compound 63)
Affinity DataEC50:  20nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells assessed as reduction in VEGFA concentration after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM373008(US9896418, Compound 163 | US10597366, Compound 163)
Affinity DataEC50:  27nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450495(CHEMBL4159016 | US10597366, Compound 206)
Affinity DataIC50: 31nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450486(CHEMBL4168279)
Affinity DataIC50: 32nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282685(US9884843, Compound 40 | 3-((4-(Difluoromethyl)-2,...)
Affinity DataEC50:  32nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450476(CHEMBL4174407 | US10597366, Compound 119)
Affinity DataIC50: 34nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372986(US9896418, Compound 25 | US10597366, Compound 25)
Affinity DataEC50:  37nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells assessed as reduction in VEGFA concentration after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM373027(US9896418, Compound 231 | US10597366, Compound 231)
Affinity DataEC50:  39nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM373008(US9896418, Compound 163 | US10597366, Compound 163)
Affinity DataEC50:  41nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells assessed as reduction in VEGFA concentration after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM373027(US9896418, Compound 231 | US10597366, Compound 231)
Affinity DataIC50: 41nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282581(US9884843, Compound 9 | 4-Bromo-5-(3-chloro-5-fluo...)
Affinity DataEC50:  43nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372988(US9896418, Compound 41 | US10597366, Compound 41)
Affinity DataIC50: 46nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282583(US9884843, Compound 10)
Affinity DataIC50: 49nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372994(US9896418, Compound 74 | US10597366, Compound 74)
Affinity DataIC50: 55nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372986(US9896418, Compound 25 | US10597366, Compound 25)
Affinity DataIC50: 60nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372986(US9896418, Compound 25 | US10597366, Compound 25)
Affinity DataEC50:  65nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450495(CHEMBL4159016 | US10597366, Compound 206)
Affinity DataEC50:  88nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282598(US9884843, Compound 14 | 5-(3-Chloro-5-fluoropheno...)
Affinity DataEC50:  100nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM372960(US9896418, Compound 1 | US10597366, Compound 1)
Affinity DataEC50:  110nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282584(US9884843, Compound 11 | 4-Chloro-5-(3-chloro-5-fl...)
Affinity DataEC50:  110nMAssay Description:Antagonist activity at HIF-2alpha in human 786-O cells co-expressing HIF responsive element after 24 hrs by ONE-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450488(CHEMBL4162878 | US10597366, Compound 128)
Affinity DataIC50: 140nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Peloton Therapeutics

Curated by ChEMBL
LigandPNGBDBM282693(US9884843, Compound 37 | 5-((4-(Difluoromethyl)-2,...)
Affinity DataIC50: 140nMAssay Description:Binding affinity to His-tagged HIF-2alpha PAS-B domain (unknown origin) after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
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