Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50007182
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50049642(3-Chloro-4,4',5'-trifluoro-4''-methanesulfonyl-[1,...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50288291(3-(4-Methanesulfonyl-phenyl)-4,4-dimethyl-2-phenyl...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of COX-2 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50474760(CG-100649 | CG100649 | Polmacoxib)
Affinity DataIC50: 3nMAssay Description:Inhibition of COX-1 in LPS-induced mouse peritoneal macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50289328(5-(4-Methanesulfonyl-phenyl)-6-phenyl-2-trifluorom...)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human COX-2 expressed in CHO-K1 cells using arachidonic acid as substrate preincubated for 15 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50153982(2-(4-Ethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-p...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human COX-2 expressed in human COS cells using arachidonic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50131593(cimicoxib | 4-[4-Chloro-5-(3-fluoro-4-methoxy-phen...)
Affinity DataIC50: 5nMAssay Description:Inhibition of COX-2 in human 143982 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50049041(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50507137(CHEMBL4533150)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50102311(3-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-6...)
Affinity DataIC50: 12nMAssay Description:Inhibition of COX-2 in human 143982 cells using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50029600(CHEMBL42485 | 5-bromo-2-(4-fluorophenyl)-3-(4-(met...)
Affinity DataIC50: 14nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50289303(5-(4-Methanesulfonyl-phenyl)-6-phenyl-imidazo[2,1-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human COX-2 transfected in CHO cells using arachidonic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50507138(CHEMBL4473838)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50049026(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50029614((SC-57666)1-[2-(4-fluorophenyl)-1-cyclopentenyl]-4...)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50103314(4-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2...)
Affinity DataIC50: 32nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid as substrate by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50076873(2-(2-Chloro-phenyl)-4-(4-fluoro-phenyl)-5-(4-metha...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50286048(2-Bromo-3-(4-fluoro-phenyl)-4-(4-methanesulfonyl-p...)
Affinity DataIC50: 80nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50286048(2-Bromo-3-(4-fluoro-phenyl)-4-(4-methanesulfonyl-p...)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50072064(CHEMBL416146 | 5-Chloro-3-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 81nMAssay Description:Inhibition of human COX-2 transfected in CHO cells using arachidonic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50125624(3-(4-Chloro-phenyl)-5-hydroxy-4-(4-methanesulfonyl...)
Affinity DataIC50: 110nMAssay Description:Inhibition of COX-2 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50091181(4-[2-(4-Methyl-thiazol-2-yl)-4-trifluoromethyl-imi...)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50103510(4-(4-Azido-phenyl)-3-phenyl-5H-furan-2-one | CHEMB...)
Affinity DataIC50: 196nMAssay Description:Inhibition of ovine COX-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of COX-2 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50075664(2-(3,5-Difluoro-phenyl)-3-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 620nMAssay Description:Inhibition of COX-2 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50150218(3-(4-Fluoro-phenoxy)-2-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50: 980nMAssay Description:Inhibition of COX-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50129503(6-Ethoxy-3-(4-methanesulfonyl-phenyl)-4-phenyl-pyr...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid as substrate preincubated for 2 mins followed by substrate addition and measured after 2 mins by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50084361(4-[3-(4-Fluoro-phenyl)-2-oxo-2,3-dihydro-oxazol-4-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of COX-2 in LPS-stimulated human whole blood after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Sheep)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50103509(1-(4-Azido-phenyl)-5-p-tolyl-3-trifluoromethyl-1H-...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of ovine COX-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50091171(3-[1-(4-Methanesulfonyl-phenyl)-4-trifluoromethyl-...)
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50057877(4-[2-(4-Fluoro-phenyl)-pyrrol-1-yl]-benzenesulfona...)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
The M.S University of Baroda

Curated by ChEMBL
LigandPNGBDBM50049655(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-p...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed