Compile Data Set for Download or QSAR
Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50002406
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022041({1-[1-{1-Cyclohexylmethyl-3-[1-(3-guanidinomethyl-...)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022036({1-[1-(1-Cyclohexylmethyl-2-hydroxy-3-{3-methyl-1-...)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022033({1-[1-{3-[1-(3-Aminomethyl-benzylcarbamoyl)-3-meth...)
Affinity DataIC50: 1nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022036({1-[1-(1-Cyclohexylmethyl-2-hydroxy-3-{3-methyl-1-...)
Affinity DataIC50: 1.20nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022042({3-[(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022042({3-[(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-...)
Affinity DataIC50: 1.40nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022041({1-[1-{1-Cyclohexylmethyl-3-[1-(3-guanidinomethyl-...)
Affinity DataIC50: 1.40nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022033({1-[1-{3-[1-(3-Aminomethyl-benzylcarbamoyl)-3-meth...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022036({1-[1-(1-Cyclohexylmethyl-2-hydroxy-3-{3-methyl-1-...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022034({3-[(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-...)
Affinity DataIC50: 6.80nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022033({1-[1-{3-[1-(3-Aminomethyl-benzylcarbamoyl)-3-meth...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022030({1-[1-(1-{2-[1-(3-Guanidinomethyl-benzylcarbamoyl)...)
Affinity DataIC50: 9nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022044({1-[1-(1-{2-[1-(3-Aminomethyl-benzylcarbamoyl)-3-m...)
Affinity DataIC50: 9nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022041({1-[1-{1-Cyclohexylmethyl-3-[1-(3-guanidinomethyl-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022034({3-[(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50016033(CHEMBL3085574 | {1-[1-{1-[2-(1-Benzylcarbamoyl-3-m...)
Affinity DataIC50: 16nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022030({1-[1-(1-{2-[1-(3-Guanidinomethyl-benzylcarbamoyl)...)
Affinity DataIC50: 20nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022039({1-[1-[1-(1-Hydroxy-2-{3-methyl-1-[(pyridin-4-ylme...)
Affinity DataIC50: 20nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50016033(CHEMBL3085574 | {1-[1-{1-[2-(1-Benzylcarbamoyl-3-m...)
Affinity DataIC50: 25nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50016033(CHEMBL3085574 | {1-[1-{1-[2-(1-Benzylcarbamoyl-3-m...)
Affinity DataIC50: 26nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022034({3-[(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-...)
Affinity DataIC50: 43nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022030({1-[1-(1-{2-[1-(3-Guanidinomethyl-benzylcarbamoyl)...)
Affinity DataIC50: 44nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022032({1-[1-[1-(1-Hydroxy-2-{3-methyl-1-[(pyridin-2-ylme...)
Affinity DataIC50: 50nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022039({1-[1-[1-(1-Hydroxy-2-{3-methyl-1-[(pyridin-4-ylme...)
Affinity DataIC50: 51nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022044({1-[1-(1-{2-[1-(3-Aminomethyl-benzylcarbamoyl)-3-m...)
Affinity DataIC50: 54nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022040({1-[1-(1-{2-[1-(1-Carbamoyl-2-phenyl-ethylcarbamoy...)
Affinity DataIC50: 63nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022040({1-[1-(1-{2-[1-(1-Carbamoyl-2-phenyl-ethylcarbamoy...)
Affinity DataIC50: 63nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022047({1-[1-(1-{2-[1-(2-Guanidino-ethylcarbamoyl)-3-meth...)
Affinity DataIC50: 64nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022031(2-(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-pr...)
Affinity DataIC50: 92nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022032({1-[1-[1-(1-Hydroxy-2-{3-methyl-1-[(pyridin-2-ylme...)
Affinity DataIC50: 92nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022038({1-[1-(1-{2-[1-(2-Amino-2-pyridin-2-yl-ethylcarbam...)
Affinity DataIC50: 100nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022044({1-[1-(1-{2-[1-(3-Aminomethyl-benzylcarbamoyl)-3-m...)
Affinity DataIC50: 110nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022045({1-[1-[1-(1-Hydroxy-2-{3-methyl-1-[(1-oxy-pyridin-...)
Affinity DataIC50: 120nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022045({1-[1-[1-(1-Hydroxy-2-{3-methyl-1-[(1-oxy-pyridin-...)
Affinity DataIC50: 120nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022037({1-[1-(1-{2-[1-(4-Benzyl-piperazine-1-carbonyl)-3-...)
Affinity DataIC50: 127nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022035({1-[1-(1-{2-[1-(2-Amino-ethylcarbamoyl)-3-methyl-b...)
Affinity DataIC50: 140nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022046({1-[1-{1-[2-(1-{3-[Bis-(2-hydroxy-ethyl)-amino]-pr...)
Affinity DataIC50: 170nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022039({1-[1-[1-(1-Hydroxy-2-{3-methyl-1-[(pyridin-4-ylme...)
Affinity DataIC50: 210nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022032({1-[1-[1-(1-Hydroxy-2-{3-methyl-1-[(pyridin-2-ylme...)
Affinity DataIC50: 240nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022037({1-[1-(1-{2-[1-(4-Benzyl-piperazine-1-carbonyl)-3-...)
Affinity DataIC50: 280nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022040({1-[1-(1-{2-[1-(1-Carbamoyl-2-phenyl-ethylcarbamoy...)
Affinity DataIC50: 290nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022037({1-[1-(1-{2-[1-(4-Benzyl-piperazine-1-carbonyl)-3-...)
Affinity DataIC50: 310nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022031(2-(2-{4-[2-(2-tert-Butoxycarbonylamino-3-phenyl-pr...)
Affinity DataIC50: 350nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022047({1-[1-(1-{2-[1-(2-Guanidino-ethylcarbamoyl)-3-meth...)
Affinity DataIC50: 710nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022048(3-(3-Aminomethyl-phenyl)-2-(2-{4-[2-(2-tert-butoxy...)
Affinity DataIC50: 880nMAssay Description:Concentration required for 50% inhibition of human plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022038({1-[1-(1-{2-[1-(2-Amino-2-pyridin-2-yl-ethylcarbam...)
Affinity DataIC50: 940nMAssay Description:Inhibition of porcine kidney reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50022038({1-[1-(1-{2-[1-(2-Amino-2-pyridin-2-yl-ethylcarbam...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed